Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.58 |
| ▸ | ATM | Q13315 | 1/20 | 0.58 |
| ▸ | GAA | P10253 | 2/20 | 0.57 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5178089 | 0.88 | ALDH1A1 (0.77) | KDM4EALDH1A1L3MBTL1ATMGAA | |
| SCHEMBL27569115 | 0.87 | KDM4E (0.74) | KDM4EALDH1A1L3MBTL1ATMMEN1 | |
| SCHEMBL22452866 | 0.87 | MEN1 (0.67) | KDM4EALDH1A1L3MBTL1ATMGAA | |
| SCHEMBL29333202 | 0.87 | KDM4E (0.67) | KDM4EALDH1A1L3MBTL1ATMHPGD | |
| Hydrochloric Acid SCHEMBL10549774 | 0.86 | KDM4E (0.73) | KDM4EALDH1A1L3MBTL1ATMMEN1 | |
| SCHEMBL7851403 | 0.84 | KDM4E (0.60) | KDM4EALDH1A1MEN1KMT2AHTT | |
| SCHEMBL27948458 | 0.84 | GAA (0.80) | KDM4EALDH1A1L3MBTL1ATMGAA | |
| SCHEMBL16695227 | 0.80 | GAA (0.58) | KDM4EALDH1A1L3MBTL1GAAS1PR5 | |
| SCHEMBL31455463 | 0.80 | LTA4H (0.56) | ALDH1A1S1PR5HTT | |
| SCHEMBL24770734 | 0.79 | ALDH1A1 (0.61) | KDM4EALDH1A1L3MBTL1ATMMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1590327-A1 | CCR8 INHIBITORS | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2005-11-02 | — | — | EP | disclosed |
| EP-1581511-A1 | CCR8 INHIBITORS | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2005-10-05 | — | — | EP | disclosed |
| WO-2004058709-A1 | CCR8 INHIBITORS | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2004-07-15 | — | — | WO | disclosed |
| WO-2004058736-A1 | CCR8 INHIBITORS | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2004-07-15 | — | — | WO | disclosed |