Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.51 |
| ▸ | FBP1 | P09467 | 1/20 | 0.45 |
| ▸ | AHR | P35869 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | TTR | P02766 | 1/20 | 0.43 |
| ▸ | PIM1 | P11309 | 1/20 | 0.43 |
| ▸ | CISD1 | Q9NZ45 | 1/20 | 0.43 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | PPARG | P37231 | 3/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28825622 | 0.87 | NFE2L2 (0.56) | NFE2L2FBP1AHRKDM4EMAPT | |
| SCHEMBL3237563 | 0.87 | NFE2L2 (0.58) | NFE2L2FBP1MAPTNPSR1TTR | |
| SCHEMBL7435417 | 0.85 | NFE2L2 (0.53) | NFE2L2FBP1MAPTNPSR1TTR | |
| SCHEMBL2093969 | 0.77 | CHRM5 (0.54) | FBP1AHRMAPTPIM1PIM2 | |
| SCHEMBL25404984 | 0.76 | NFE2L2 (0.45) | NFE2L2FBP1AHRKDM4EMAPT | |
| SCHEMBL18240610 | 0.76 | NFE2L2 (0.54) | NFE2L2FBP1MAPTTDP1NPC1 | |
| SCHEMBL13790316 | 0.75 | NFE2L2 (0.82) | NFE2L2FBP1AHRMAPTNPSR1 | |
| SCHEMBL543039 | 0.75 | NFE2L2 (0.55) | NFE2L2FBP1MAPTNPSR1TTR | |
| SCHEMBL11405276 | 0.74 | MAPT (0.53) | NFE2L2FBP1AHRKDM4EGAA | |
| SCHEMBL28825569 | 0.74 | NFE2L2 (0.46) | NFE2L2FBP1MAPTNPSR1TTR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1519932-A1 | BISARYLSULFONAMIDE COMPOUNDS AND THEIR USE IN CANCER THERAPY | Cyclacel Limited (GB) | 2005-04-06 | — | — | EP | claimed |
| WO-2004005278-A1 | BISARYLSULFONAMIDE COMPOUNDS AND THEIR USE IN CANCER THERAPY | CYCLACEL LIMITED (GB) | 2004-01-15 | — | — | WO | claimed |