Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.55 |
| ▸ | FBP1 | P09467 | 1/20 | 0.51 |
| ▸ | MGLL | Q99685 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | P4HB | P07237 | 2/20 | 0.45 |
| ▸ | TTR | P02766 | 1/20 | 0.45 |
| ▸ | PIM1 | P11309 | 1/20 | 0.45 |
| ▸ | CISD1 | Q9NZ45 | 1/20 | 0.45 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27945788 | 0.83 | NFE2L2 (0.61) | NFE2L2FBP1TSHRMAPK1MEN1 | |
| SCHEMBL3237563 | 0.82 | NFE2L2 (0.58) | NFE2L2FBP1MGLLTSHRMAPK1 | |
| SCHEMBL5537772 | 0.80 | NFE2L2 (0.56) | NFE2L2FBP1MGLLTSHRMAPK1 | |
| SCHEMBL543252 | 0.80 | NFE2L2 (0.56) | NFE2L2FBP1MGLLTSHRMAPK1 | |
| SCHEMBL15741569 | 0.78 | NFE2L2 (0.55) | NFE2L2FBP1MGLLTSHRMAPK1 | |
| SCHEMBL127539 | 0.78 | NFE2L2 (0.55) | NFE2L2FBP1MGLLTSHRMAPK1 | |
| SCHEMBL13790316 | 0.78 | NFE2L2 (0.82) | NFE2L2FBP1TSHRMAPK1MEN1 | |
| SCHEMBL543469 | 0.78 | NFE2L2 (0.59) | NFE2L2FBP1MGLLTSHRMAPK1 | |
| SCHEMBL216268 | 0.78 | NFE2L2 (0.55) | NFE2L2FBP1MGLLTSHRMAPK1 | |
| SCHEMBL67201 | 0.78 | FBP1 (0.56) | NFE2L2FBP1TSHRMAPK1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102203060-B | 3-(benzylamino)-pyrrolidine derivatives and their use as nk-3 receptor antagonists | HOFFMANN LA ROCHE | 2014-09-24 | — | — | CN | disclosed |
| CN-101374817-B | Trisubstituted amine compounds as inhibitors of cholesteryl ester transfer protein CETP | MITSUBISHI TANABE PHARMA CORP | 2014-07-30 | — | — | CN | disclosed |
| CN-103497188-A | Compounds modulating c-fms and/or c-kit activity and uses therefor | PLEXXIKON INC | 2014-01-08 | — | — | CN | disclosed |
| CN-101605787-B | Compounds that modulate c-fms and/or c-kit activity and uses thereof | PLEXXIKON INC | 2013-11-13 | — | — | CN | disclosed |
| CN-103172562-A | Trisubstituted amine compounds as inhibitors of cholesteryl ester transfer protein CETP | TANABE SEIYAKU CO | 2013-06-26 | — | — | CN | disclosed |
| CN-101910138-B | Herbicidal compounds | SYNGENTA LTD | 2013-06-26 | — | — | CN | disclosed |
| CN-101959516-B | Combination therapy comprising quinoxaline PI3K alpha inhibitors for the treatment of cancer | EXELIXIS INC | 2013-05-08 | — | — | CN | disclosed |
| EP-2414330-A2 | PIPERIDINE AND PIPERAZINE DERIVATIVES AS AUTOTAXIN INHIBITORS | Merck Patent GmbH (DE) | 2012-02-08 | — | — | EP | disclosed |
| WO-2010115491-A2 | PIPERIDINE AND PIPERAZINE DERIVATIVES AS AUTOTAXIN INHIBITORS | MERCK PATENT GMBH (DE) | 2010-10-14 | — | — | WO | disclosed |