Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | AOC3 | Q16853 | 3/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | MTNR1A | P48039 | 4/20 | 0.43 |
| ▸ | MTNR1B | P49286 | 4/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.43 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.43 |
| ▸ | CASR | P41180 | 2/20 | 0.42 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6202675 | 0.87 | TP53 (0.46) | L3MBTL1ALDH1A1 | |
| SCHEMBL10607023 | 0.83 | L3MBTL1 (0.55) | L3MBTL1AOC3MTNR1AMTNR1BCHRM2 | |
| SCHEMBL6203525 | 0.79 | AOC3 (0.41) | AOC3 | |
| SCHEMBL28729377 | 0.78 | AOC3 (0.51) | L3MBTL1ALDH1A1HPGDAOC3MTNR1A | |
| SCHEMBL10435907 | 0.77 | TSHR (0.42) | L3MBTL1ALDH1A1 | |
| SCHEMBL10608596 | 0.75 | L3MBTL1 (0.48) | L3MBTL1AOC3MTNR1AMTNR1B | |
| SCHEMBL2093766 | 0.75 | L3MBTL1 (0.53) | L3MBTL1ALDH1A1AOC3CHRM2CHRM1 | |
| SCHEMBL8883399 | 0.75 | AOC3 (0.45) | L3MBTL1ALDH1A1HPGDAOC3ALOX15 | |
| SCHEMBL6204864 | 0.73 | L3MBTL1 (0.51) | L3MBTL1ALDH1A1AOC3MTNR1AMTNR1B | |
| SCHEMBL8053712 | 0.73 | L3MBTL1 (0.51) | L3MBTL1ALDH1A1AOC3CHRM2CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1506175-A1 | N-SUBSTITUTED TRICYCLIC 3-AMINOPYRAZOLES AS PDGF RECEPTOR INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2005-02-16 | — | — | EP | disclosed |
| WO-2003097609-A1 | N-SUBSTITUTED TRICYCLIC 3-AMINOPYRAZOLES AS PDFG RECEPTOR INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2003-11-27 | — | — | WO | disclosed |