Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 10/20 | 0.55 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.37 |
| ▸ | RUNX1 | Q01196 | 1/20 | 0.36 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.36 |
| ▸ | PDE2A | O00408 | 1/20 | 0.35 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6204110 | 0.86 | CRHR1 (0.58) | CRHR1SCN9ARUNX1 | |
| SCHEMBL6203432 | 0.86 | CRHR1 (0.53) | CRHR1SCN9APDE2A | |
| SCHEMBL6203296 | 0.85 | CRHR1 (0.57) | CRHR1SCN9ARUNX1 | |
| SCHEMBL6202563 | 0.85 | CRHR1 (0.57) | CRHR1SCN9ARUNX1 | |
| SCHEMBL6603304 | 0.85 | CRHR1 (0.46) | CRHR1SCN9ARUNX1FFAR4FFAR1 | |
| SCHEMBL5445901 | 0.84 | CRHR1 (0.62) | CRHR1SCN9A | |
| SCHEMBL6204281 | 0.81 | CRHR1 (0.38) | CRHR1 | |
| SCHEMBL6602770 | 0.80 | CRHR1 (0.54) | CRHR1SCN9ARUNX1FFAR4FFAR1 | |
| SCHEMBL6609362 | 0.79 | CRHR1 (0.46) | CRHR1SCN9ARUNX1FFAR4 | |
| SCHEMBL5417192 | 0.79 | CRHR1 (0.62) | CRHR1SCN9ARUNX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1554258-A1 | 5-SUBSTITUTED-2-ARYLPYRAZINES AS MODULATORS OF CRF RECEPTORS | NEUROGEN CORPORATION (US) | 2005-07-20 | — | — | EP | claimed |
| WO-2004018437-A1 | 5-SUBSTITUTED-2-ARYLPYRAZINES AS MODULATORS OF CRF RECEPTORS | NEUROGEN CORPORATION (US) | 2004-03-04 | — | — | WO | claimed |