Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.58 |
| ▸ | POLB | P06746 | 2/20 | 0.56 |
| ▸ | RAB9A | P51151 | 2/20 | 0.56 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | BACE1 | P56817 | 2/20 | 0.49 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6207917 | 0.90 | RAB9A (0.56) | HPGDPOLBRAB9AMAPK14MAPT | |
| SCHEMBL6205245 | 0.90 | HPGD (0.55) | HPGDPOLBRAB9AMAPTADORA2A | |
| SCHEMBL6206287 | 0.88 | HPGD (0.60) | HPGDPOLBRAB9AMAPK14MAPT | |
| SCHEMBL6205185 | 0.88 | HPGD (0.56) | HPGDPOLBRAB9AMAPK14MAPT | |
| SCHEMBL6205238 | 0.87 | NPC1 (0.55) | HPGDPOLBRAB9AMAPTALDH1A1 | |
| SCHEMBL6205565 | 0.86 | POLB (0.62) | HPGDPOLBRAB9AMAPTBACE1 | |
| Hydrochloric Acid SCHEMBL6206718 | 0.86 | NPC1 (0.54) | HPGDPOLBRAB9AMAPTALDH1A1 | |
| SCHEMBL6206009 | 0.83 | HPGD (0.58) | HPGDPOLBRAB9AMAPTALDH1A1 | |
| SCHEMBL6204455 | 0.83 | POLB (0.53) | HPGDPOLBRAB9AMAPTALDH1A1 | |
| SCHEMBL6207397 | 0.83 | MAPT (0.53) | HPGDPOLBRAB9AMAPTBACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1177177-B1 | SUBSTITUTED 4-OXO-QUINOLINE-3-CARBOXAMIDES: GABA BRAIN RECEPTOR LIGANDS | NEUROGEN CORP (US) | 2005-02-23 | — | — | EP | claimed |