Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 2/20 | 0.46 |
| ▸ | ELANE | P08246 | 6/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | CES2 | O00748 | 1/20 | 0.39 |
| ▸ | CES1 | P23141 | 1/20 | 0.39 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.38 |
| ▸ | BCHE | P06276 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14935500 | 0.78 | PRMT1 (0.54) | MEN1KMT2AALDH1A1NPC1CES2 | |
| SCHEMBL7260785 | 0.78 | PRMT1 (0.54) | MEN1KMT2AALDH1A1NPC1CES2 | |
| SCHEMBL10995027 | 0.78 | PRMT1 (0.54) | MEN1KMT2AALDH1A1NPC1CES2 | |
| SCHEMBL6206291 | 0.73 | ALOX5 (0.46) | ALOX5ELANEMEN1KMT2AALDH1A1 | |
| SCHEMBL6205771 | 0.73 | ALOX5 (0.46) | ALOX5ELANEMEN1KMT2AALDH1A1 | |
| SCHEMBL6205778 | 0.73 | ALOX5 (0.46) | ALOX5ELANEMEN1KMT2AALDH1A1 | |
| SCHEMBL11147391 | 0.73 | ALOX5 (0.49) | ALOX5ELANEMEN1KMT2AALDH1A1 | |
| SCHEMBL2184443 | 0.73 | ALDH1A1 (0.44) | MEN1KMT2AALDH1A1NPC1CES2 | |
| SCHEMBL1174501 | 0.73 | ALDH1A1 (0.44) | MEN1KMT2AALDH1A1NPC1CES2 | |
| SCHEMBL3054716 | 0.72 | ALOX5 (0.51) | ALOX5ELANEMEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1532128-A1 | INHIBITORS OF HCV NS5B POLYMERASE | Pharmacia & Upjohn Company LLC (US) | 2005-05-25 | — | — | EP | disclosed |
| WO-2004002977-A1 | INHIBITORS OF HCV NS5B POLYMERASE | PHARMACIA & UPJOHN COMPANY LLC (US) | 2004-01-08 | — | — | WO | disclosed |