Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | ELANE | P08246 | 1/20 | 0.39 |
| ▸ | CES2 | O00748 | 1/20 | 0.39 |
| ▸ | CES1 | P23141 | 1/20 | 0.39 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.37 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.37 |
| ▸ | NSD2 | O96028 | 1/20 | 0.37 |
| ▸ | TLR4 | O00206 | 1/20 | 0.36 |
| ▸ | TLR2 | O60603 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6205771 | 1.00 | ALOX5 (0.46) | ALOX5ALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL28789945 | 0.74 | CES2 (0.46) | ALDH1A1MEN1KMT2AELANECES2 | |
| SCHEMBL6205774 | 0.73 | ALOX5 (0.46) | ALOX5ALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL6205778 | 0.73 | ALOX5 (0.46) | ALOX5ALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL1174501 | 0.73 | ALDH1A1 (0.44) | ALDH1A1MEN1KMT2ACES2CES1 | |
| SCHEMBL6832635 | 0.73 | CES2 (0.44) | ALDH1A1MEN1KMT2ACES2CES1 | |
| SCHEMBL11147391 | 0.73 | ALOX5 (0.49) | ALOX5ALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL6832632 | 0.73 | CES2 (0.44) | ALDH1A1MEN1KMT2ACES2CES1 | |
| SCHEMBL3054716 | 0.72 | ALOX5 (0.51) | ALOX5ALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL6204752 | 0.72 | ELANE (0.52) | ALDH1A1KMT2AELANECES2CES1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1532128-A1 | INHIBITORS OF HCV NS5B POLYMERASE | Pharmacia & Upjohn Company LLC (US) | 2005-05-25 | — | — | EP | disclosed |
| WO-2004002977-A1 | INHIBITORS OF HCV NS5B POLYMERASE | PHARMACIA & UPJOHN COMPANY LLC (US) | 2004-01-08 | — | — | WO | disclosed |