Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NUDT1 | P36639 | 1/20 | 0.60 |
| ▸ | METAP1 | P53582 | 2/20 | 0.53 |
| ▸ | METAP2 | P50579 | 1/20 | 0.53 |
| ▸ | PDE5A | O76074 | 4/20 | 0.49 |
| ▸ | AURKA | O14965 | 7/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | HPSE | Q9Y251 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1170747 | 0.78 | METAP1 (0.72) | NUDT1METAP1METAP2PDE5AAURKA | |
| SCHEMBL31490802 | 0.77 | NUDT1 (0.62) | NUDT1METAP1METAP2PDE5AAURKA | |
| SCHEMBL239645 | 0.77 | NUDT1 (0.62) | NUDT1METAP1METAP2PDE5AAURKA | |
| SCHEMBL805045 | 0.75 | NUDT1 (0.60) | NUDT1METAP1METAP2PDE5AAURKA | |
| SCHEMBL21389521 | 0.75 | NUDT1 (0.60) | NUDT1METAP1METAP2PDE5AAURKA | |
| SCHEMBL24520478 | 0.75 | NUDT1 (0.60) | NUDT1METAP1METAP2PDE5AAURKA | |
| SCHEMBL6962055 | 0.75 | NUDT1 (0.60) | NUDT1METAP1METAP2PDE5AAURKA | |
| SCHEMBL3974198 | 0.75 | NUDT1 (0.60) | NUDT1METAP1METAP2PDE5AAURKA | |
| SCHEMBL1427745 | 0.75 | NUDT1 (0.60) | NUDT1METAP1METAP2PDE5AAURKA | |
| SCHEMBL323981 | 0.75 | NUDT1 (0.60) | NUDT1METAP1METAP2PDE5AAURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 104 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016029146-A1 | SPECIFIC INHIBITORS OF METHIONYL-TRNA SYNTHETASE | UNIVERSITY OF WASHINGTON (US) | 2016-02-25 | — | — | WO | claimed |
| WO-2025076501-A1 | HIGH THROUGHPUT PARALLEL SYNTHESIS OF SMALL MOLECULE DEGRADERS | THE SCRIPPS RESEARCH INSTITUTE (US) | 2025-04-10 | — | — | WO | disclosed |
| CN-116768887-A | Preparation method of iridescent and dual-band fluorescent emission material | 桂林理工大学 | 2023-09-19 | — | — | CN | disclosed |
| US-20220389019-A1 | TrkB POSITIVE ALLOSTERIC MODULATORS | INSERM - INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE (FR) | 2022-12-08 | — | — | US | disclosed |
| EP-4010341-A1 | TRKB POSITIVE ALLOSTERIC MODULATORS | Université de Strasbourg (FR) | 2022-06-15 | — | — | EP | disclosed |
| EP-3131897-B1 | FACTOR IXA INHIBITORS | MERCK SHARP & DOHME (US) | 2022-06-15 | — | — | EP | disclosed |
| CN-114450006-A | TrkB positive allosteric modulators | 斯特拉斯堡大学 | 2022-05-06 | — | — | CN | disclosed |
| US-20220089592-A1 | IMIDAZO[1,2-A]PYRIDINYL DERIVATIVES AS IRAK4 INHIBITORS | BIOGEN MA INC. | 2022-03-24 | — | — | US | disclosed |
| EP-3911652-A1 | IMIDAZO[1,2-A]PYRIDINYL DERIVATIVES AS IRAK4 INHIBITORS | Biogen MA Inc. (US) | 2021-11-24 | — | — | EP | disclosed |
| WO-2021023858-A1 | TrkB POSITIVE ALLOSTERIC MODULATORS | UNIVERSITÉ DE STRASBOURG (FR) | 2021-02-11 | — | — | WO | disclosed |
| WO-2001032264-A1 | ARYL OLEFINIC AZACYCLIC, AND ARYL ACETYLENIC AZACYCLIC COMPOUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE AS INHIBITORS OF NICOTINIC CHOLINERGIC RECEPTORS | TARGACEPT, INC. (US) | 2001-05-10 | — | — | WO | disclosed |
| US-6214840-B1 | FUNGICIDES; BACTERICIDES | BAYER AKTIENGESELLSCHAFT (DE) | 2001-04-10 | — | — | US | disclosed |
| WO-2000075110-A1 | PHARMACEUTICAL COMPOSITIONS AND METHODS FOR USE | TARGACEPT, INC. (US) | 2000-12-14 | — | — | WO | disclosed |
| EP-0966467-A1 | ANNULATED AZOLE DERIVATIVES USEFUL AS MICROBICIDAL AGENTS | Bayer Aktiengesellschaft (DE) | 1999-12-29 | — | — | EP | disclosed |
| US-5977028-A | Substituted phenylheterocyclic herbicides | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1999-11-02 | — | — | US | disclosed |
| EP-0626962-B1 | SUBSTITUTED PHENYLHETEROCYCLIC HERBICIDES | DU PONT (US) | 1999-03-17 | — | — | EP | disclosed |
| WO-1998039331-A1 | ANNULATED AZOLE DERIVATIVES USEFUL AS MICROBICIDAL AGENTS | BAYER AKTIENGESELLSCHAFT (DE) | 1998-09-11 | — | — | WO | disclosed |
| US-5670455-A | Substituted phenylheterocyclic herbicides | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1997-09-23 | — | — | US | disclosed |
| EP-0626962-A1 | SUBSTITUTED PHENYLHETEROCYCLIC HERBICIDES | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1994-12-07 | — | — | EP | disclosed |
| WO-1993015074-A1 | SUBSTITUTED PHENYLHETEROCYCLIC HERBICIDES | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1993-08-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220389019-A1 | TrkB POSITIVE ALLOSTERIC MODULATORS | HTT, NTRK2, BDNF | NUDT1 1129/4885METAP1 4753/4885METAP2 4702/4885 |
| US-20220089592-A1 | IMIDAZO[1,2-A]PYRIDINYL DERIVATIVES AS IRAK4 INHIBITORS | IRAK4, IRAK2, IRAK1 | NUDT1 3139/4885METAP1 3844/4885METAP2 4516/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.