Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | SIRT2 | Q8IXJ6 | 7/20 | 0.43 |
| ▸ | SIRT3 | Q9NTG7 | 7/20 | 0.43 |
| ▸ | SIRT1 | Q96EB6 | 6/20 | 0.43 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | F2 | P00734 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.38 |
| ▸ | PARP10 | Q53GL7 | 2/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.38 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6079543 | 0.81 | KMT2A (0.49) | MEN1KMT2ASMN1; SMN2SIRT2SIRT3 | |
| SCHEMBL6079306 | 0.78 | CYP4F2 (0.45) | SMN1; SMN2MRGPRX4RXFP1MAPK1 | |
| SCHEMBL6079584 | 0.76 | MAOB (0.45) | MEN1MRGPRX4RXFP1MAOB | |
| SCHEMBL2492332 | 0.72 | KMT2A (0.47) | MEN1KMT2AMAPK1TSHR | |
| SCHEMBL306075 | 0.72 | ADORA3 (0.50) | MEN1KMT2ASMN1; SMN2SIRT2SIRT3 | |
| SCHEMBL30880791 | 0.72 | ADORA3 (0.50) | MEN1KMT2ASMN1; SMN2SIRT2SIRT3 | |
| SCHEMBL5249598 | 0.72 | KMT2A (0.65) | MEN1KMT2ASMN1; SMN2SIRT2PARP10 | |
| SCHEMBL28652467 | 0.71 | RAB9A (0.55) | MEN1KMT2AF2PARP10MAOB | |
| SCHEMBL27526614 | 0.71 | KMT2A (0.68) | MEN1KMT2ASMN1; SMN2MAOB | |
| SCHEMBL2723540 | 0.71 | KMT2A (0.68) | MEN1KMT2ASMN1; SMN2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1545523-A1 | 3-&-grave;(HETERO) ARYLMETHOXY ! PYRIDINES AND THEIR ANALOGUES ASP38 MAP KINASE INHIBITORS | Astex Technology Limited (GB) | 2005-06-29 | — | — | EP | disclosed |
| WO-2005002673-A1 | RAF KINASE INHIBITORS | ASTEX THERAPEUTICS LIMITED (GB) | 2005-01-13 | — | — | WO | disclosed |
| WO-2004004720-A1 | 3-`(HETERO) ARYLMETHOXY ! PYRIDINES AND THEIR ANALOGUES AS P38 MAP KINASE INHIBITORS | ASTEX TECHNOLOGY LIMITED (GB) | 2004-01-15 | — | — | WO | disclosed |