Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.37 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.37 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | DTYMK | P23919 | 1/20 | 0.36 |
| ▸ | CES2 | O00748 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 3/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5913534 | 1.00 | RXRA (0.44) | RXRAALDH1A1LMNANPC1RAB9A | |
| SCHEMBL5913631 | 0.89 | MAPT (0.36) | ALDH1A1LMNANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL5463384 | 0.88 | NPC1 (0.41) | ALDH1A1LMNANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL2853361 | 0.83 | ALDH1A1 (0.38) | RXRAALDH1A1LMNAPOLBTDP1 | |
| SCHEMBL22128468 | 0.81 | ALDH1A1 (0.40) | ALDH1A1LMNANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL19405909 | 0.81 | GPR35 (0.43) | ALDH1A1LMNASMN1; SMN2POLBTDP1 | |
| SCHEMBL8116981 | 0.81 | ALDH1A1 (0.39) | ALDH1A1LMNASMN1; SMN2POLBTDP1 | |
| SCHEMBL29288338 | 0.80 | NR1H4 (0.47) | RXRANPC1RAB9A | |
| SCHEMBL4817300 | 0.80 | RXRA (0.50) | RXRAALDH1A1LMNANPC1RAB9A | |
| SCHEMBL5452217 | 0.79 | MAPT (0.41) | ALDH1A1LMNANPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1562898-A1 | INDOLE DERIVATIVES AS SOMATOSTATIN AGONISTS OR ANTAGONISTS | Takeda Pharmaceutical Company Limited (JP) | 2005-08-17 | — | — | EP | disclosed |
| WO-2004046107-A1 | INDOLE DERIVATIVES AS SOMATOSTATIN AGONISTS OR ANTAGONISTS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2004-06-03 | — | — | WO | disclosed |