Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | FPR1 | P21462 | 1/20 | 0.40 |
| ▸ | FPR2 | P25090 | 1/20 | 0.40 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.40 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.39 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | NPY2R | P49146 | 2/20 | 0.37 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.36 |
| ▸ | EML4 | Q9HC35 | 1/20 | 0.36 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6207573 | 0.88 | FPR1 (0.41) | FPR1FPR2PDE10AAAK1KDM4D | |
| SCHEMBL1749749 | 0.86 | PTGS1 (0.47) | PTGS1PTGS2FPR1FPR2MAPT | |
| SCHEMBL29772884 | 0.82 | PDE10A (0.45) | FPR1FPR2PDE10AAAK1KDM4D | |
| SCHEMBL4294688 | 0.82 | PDE10A (0.43) | FPR1FPR2PDE10AAAK1KDM4D | |
| SCHEMBL31485219 | 0.82 | PDE10A (0.43) | FPR1FPR2PDE10AAAK1KDM4D | |
| SCHEMBL24628490 | 0.82 | PDE10A (0.45) | FPR1FPR2PDE10AAAK1KDM4D | |
| SCHEMBL29772858 | 0.82 | PDE10A (0.45) | FPR1FPR2PDE10AAAK1KDM4D | |
| SCHEMBL4288048 | 0.82 | PDE10A (0.43) | FPR1FPR2PDE10AAAK1KDM4D | |
| SCHEMBL4294928 | 0.79 | ALDH1A1 (0.50) | PDE10AALDH1A1MAPTMAPK1HTT | |
| SCHEMBL1750650 | 0.78 | PDE10A (0.40) | PDE10AAAK1HSD11B1MAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1597228-A2 | SUBSTITUTED N-ARYLHETEROCYCLES, METHOD FOR PRODUCTION AND USE THEREOF AS MEDICAMENTS | Sanofi-Aventis Deutschland GmbH (DE) | 2005-11-23 | — | — | EP | disclosed |
| WO-2004072025-A2 | SUBSTITUTED N-ARYLHETEROCYCLES, METHOD FOR PRODUCTION AND USE THEREOF AS MEDICAMENTS | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2004-08-26 | — | — | WO | disclosed |