Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.50 |
| ▸ | NPC1 | O15118 | 3/20 | 0.50 |
| ▸ | RAB9A | P51151 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.50 |
| ▸ | TP53 | P04637 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | CASP1 | P29466 | 1/20 | 0.50 |
| ▸ | CASP7 | P55210 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | CA12 | O43570 | 1/20 | 0.49 |
| ▸ | CA1 | P00915 | 1/20 | 0.49 |
| ▸ | CA2 | P00918 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3406339 | 0.86 | MAPT (0.55) | NOTUMALDH1A1MAPTTSHRNPSR1 | |
| SCHEMBL3820953 | 0.81 | NOTUM (0.41) | NOTUMALDH1A1MAPTPOLBCYP2C9 | |
| SCHEMBL1749207 | 0.79 | NOTUM (0.81) | NOTUMALDH1A1NPC1RAB9AMAPT | |
| SCHEMBL6206254 | 0.79 | ALDH1A1 (0.51) | NOTUMALDH1A1MAPTTSHRNPSR1 | |
| SCHEMBL27988992 | 0.78 | NOTUM (0.46) | NOTUMALDH1A1NPC1RAB9AMAPT | |
| SCHEMBL9501600 | 0.77 | NOTUM (0.68) | NOTUMALDH1A1NPC1RAB9AMAPT | |
| SCHEMBL12093605 | 0.77 | LMNA (0.48) | NOTUMALDH1A1NPC1RAB9AMAPT | |
| SCHEMBL16595544 | 0.77 | NOTUM (0.67) | NOTUMALDH1A1NPC1RAB9AMAPT | |
| Hydrochloric Acid SCHEMBL9499696 | 0.76 | NOTUM (0.66) | NOTUMALDH1A1NPC1RAB9AMAPT | |
| SCHEMBL3406337 | 0.76 | CYP2C19 (0.55) | NOTUMALDH1A1MAPTMAPK1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1597228-A2 | SUBSTITUTED N-ARYLHETEROCYCLES, METHOD FOR PRODUCTION AND USE THEREOF AS MEDICAMENTS | Sanofi-Aventis Deutschland GmbH (DE) | 2005-11-23 | — | — | EP | disclosed |
| WO-2004072025-A2 | SUBSTITUTED N-ARYLHETEROCYCLES, METHOD FOR PRODUCTION AND USE THEREOF AS MEDICAMENTS | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2004-08-26 | — | — | WO | disclosed |