Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 1/20 | 0.30 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.30 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.30 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27294926 | 0.82 | TP53 (0.32) | — | |
| SCHEMBL23454258 | 0.73 | — | — | |
| SCHEMBL9030036 | 0.73 | — | — | |
| SCHEMBL23454338 | 0.73 | — | — | |
| SCHEMBL14256130 | 0.73 | — | — | |
| SCHEMBL695303 | 0.70 | — | — | |
| SCHEMBL6547840 | 0.70 | — | — | |
| SCHEMBL9340831 | 0.70 | — | — | |
| SCHEMBL9340828 | 0.70 | — | — | |
| SCHEMBL7157029 | 0.69 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6965034-B2 | Synthesis of epothilones, intermediates thereto and analogues thereof | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 2005-11-15 | — | — | US | disclosed |
| EP-1058679-B1 | SYNTHESIS OF EPOTHILONES, INTERMEDIATES THERETO AND ANALOGUES THEROF | SLOAN KETTERING INST CANCER (US) | 2005-10-19 | — | — | EP | disclosed |
| US-20040260098-A1 | Synthesis of epothilones, intermediates thereto and analogues thereof | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2004-12-23 | — | — | US | disclosed |
| US-20030208080-A1 | Synthesis of epothilones, intermediates thereto and analogues thereof | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2003-11-06 | — | — | US | disclosed |
| US-6603023-B2 | Synthetic methods for preparing intermediates for the preparation of epothilones A and B, and desoxyepothilones A and B, and related compounds useful as anticancer therapeutics | SLOAN KETTERING INSTITUTE FOR CANCER RESEARCH | 2003-08-05 | — | — | US | disclosed |
| US-20030105330-A1 | Synthesis of epothilones, intermediates thereto and analogues thereof | NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR | 2003-06-05 | — | — | US | disclosed |
| US-20030069277-A1 | Synthesis of epothilones, intermediates thereto and analogues thereof | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2003-04-10 | — | — | US | disclosed |
| US-6316630-B1 | TREATING EPOTHILONE TO DEOXYGENATE THE EPOTHILONE, AND THEREBY TO PROVIDE THE DESOXYEPOTHILONE | SLOAN KETTERING INSTITUTE FOR CANCER RESEARCH | 2001-11-13 | — | — | US | disclosed |
| US-6204388-B1 | USING BLOCKING AGENT | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH | 2001-03-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030208080-A1 | Synthesis of epothilones, intermediates thereto and analogues thereof | DHPS, PPOX, DOHH | CHRM2 4885/4885CHRM4 4882/4885CHRM1 4881/4885 |
| US-20030105330-A1 | Synthesis of epothilones, intermediates thereto and analogues thereof | DHPS, PPOX, DOHH | CHRM2 4885/4885CHRM4 4882/4885CHRM1 4881/4885 |
| US-20030069277-A1 | Synthesis of epothilones, intermediates thereto and analogues thereof | DHPS, PPOX, DOHH | CHRM2 4885/4885CHRM4 4882/4885CHRM1 4881/4885 |
| US-20040260098-A1 | Synthesis of epothilones, intermediates thereto and analogues thereof | DHPS, PPOX, DOHH | CHRM2 4885/4885CHRM4 4882/4885CHRM1 4881/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.