Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.58 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.58 |
| ▸ | HPGD | P15428 | 2/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.53 |
| ▸ | POLB | P06746 | 3/20 | 0.51 |
| ▸ | MPO | P05164 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.48 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6205334 | 0.99 | MAPT (0.57) | MAPTRXFP1ALDH1A1HPGDKMT2A | |
| SCHEMBL6204754 | 0.99 | MAPT (0.59) | MAPTRXFP1ALDH1A1HPGDKMT2A | |
| Hydrochloric Acid SCHEMBL6203546 | 0.98 | MAPT (0.58) | MAPTRXFP1ALDH1A1HPGDKMT2A | |
| SCHEMBL6206415 | 0.86 | KDM4E (0.60) | MAPTALDH1A1HPGDHRH3POLB | |
| SCHEMBL6203893 | 0.84 | POLB (0.72) | MAPTALDH1A1HPGDKMT2AHRH3 | |
| SCHEMBL6206611 | 0.83 | POLB (0.73) | MAPTRXFP1ALDH1A1HPGDKMT2A | |
| SCHEMBL6207397 | 0.82 | MAPT (0.53) | MAPTRXFP1ALDH1A1HPGDKMT2A | |
| SCHEMBL6208399 | 0.81 | RAB9A (0.58) | ALDH1A1HPGDHRH3RAB9A | |
| SCHEMBL6205202 | 0.81 | NHERF1 (0.53) | HRH3POLBHDAC1HDAC6NPC1 | |
| SCHEMBL6204128 | 0.80 | NHERF1 (0.68) | MAPTRXFP1POLBADORA2AADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1177177-B1 | SUBSTITUTED 4-OXO-QUINOLINE-3-CARBOXAMIDES: GABA BRAIN RECEPTOR LIGANDS | NEUROGEN CORP (US) | 2005-02-23 | — | — | EP | claimed |
| US-6413956-B1 | AGONISTS, ANTAGONISTS OR INVERSE AGONISTS AND LOCALIZATION PROBES FOR GAMMA AMINOBUTYRIC ACID BRAIN RECEPTORS; ANXIETY, DEPRESSION, DOWN SYNDROME, SLEEP AND SEIZURE DISORDERS, OVERDOSE WITH BENZODIAZEPINE DRUGS AND MEMORY ENHANCEMENT | NEUROGEN CORPORATION | 2002-07-02 | — | — | US | claimed |