Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | ELANE | P08246 | 4/20 | 0.44 |
| ▸ | SRC | P12931 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 4/20 | 0.42 |
| ▸ | RAB9A | P51151 | 4/20 | 0.42 |
| ▸ | CES2 | O00748 | 1/20 | 0.42 |
| ▸ | CES1 | P23141 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6207375 | 1.00 | TSHR (0.47) | TSHRELANESRCCYP1A2NPC1 | |
| SCHEMBL6206484 | 0.90 | LMNA (0.45) | TSHRELANENPC1RAB9ACES2 | |
| SCHEMBL6206060 | 0.86 | TSHR (0.47) | TSHRELANECYP1A2NPC1RAB9A | |
| SCHEMBL457034 | 0.85 | TSHR (0.54) | TSHRSRCNPC1RAB9ACES2 | |
| SCHEMBL27876289 | 0.83 | TSHR (0.52) | TSHRSRCNPC1RAB9ACES2 | |
| SCHEMBL27892981 | 0.83 | TSHR (0.52) | TSHRSRCNPC1RAB9ACES2 | |
| SCHEMBL9296117 | 0.78 | CES2 (0.54) | ELANENPC1RAB9ACES2CES1 | |
| SCHEMBL9562937 | 0.78 | ELANE (0.52) | TSHRELANECYP1A2CES2CES1 | |
| SCHEMBL6204752 | 0.78 | ELANE (0.52) | TSHRELANECYP1A2CES2CES1 | |
| SCHEMBL6206488 | 0.77 | LMNA (0.45) | TSHRELANENPC1RAB9ACES2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1532128-A1 | INHIBITORS OF HCV NS5B POLYMERASE | Pharmacia & Upjohn Company LLC (US) | 2005-05-25 | — | — | EP | disclosed |
| WO-2004002977-A1 | INHIBITORS OF HCV NS5B POLYMERASE | PHARMACIA & UPJOHN COMPANY LLC (US) | 2004-01-08 | — | — | WO | disclosed |