Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.57 |
| ▸ | RAB9A | P51151 | 1/20 | 0.57 |
| ▸ | CNR2 | P34972 | 18/20 | 0.56 |
| ▸ | CNR1 | P21554 | 10/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6206149 | 1.00 | NPC1 (0.57) | NPC1RAB9ACNR2CNR1 | |
| SCHEMBL6085332 | 0.78 | CNR2 (0.58) | NPC1RAB9ACNR2CNR1 | |
| SCHEMBL7736408 | 0.78 | CNR2 (0.58) | NPC1RAB9ACNR2CNR1 | |
| SCHEMBL6205946 | 0.76 | RAB9A (0.51) | NPC1RAB9ACNR2CNR1 | |
| SCHEMBL6205950 | 0.76 | RAB9A (0.51) | NPC1RAB9ACNR2CNR1 | |
| SCHEMBL12709415 | 0.75 | P2RX7 (0.61) | NPC1RAB9ACNR2CNR1 | |
| SCHEMBL7691769 | 0.75 | EGLN1 (0.56) | NPC1RAB9ACNR2CNR1 | |
| SCHEMBL125290 | 0.73 | LMNA (0.51) | NPC1RAB9A | |
| SCHEMBL3458121 | 0.73 | SMN1; SMN2 (0.53) | NPC1RAB9A | |
| SCHEMBL6085305 | 0.73 | PLK1 (0.61) | NPC1RAB9ACNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1595871-A2 | Metabotropic glutamate receptor antagonists and their use for treating central nervous system diseases | NPS PHARMACEUTICALS, INC. (US) | 2005-11-16 | — | — | EP | disclosed |