Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1D | P25100 | 3/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.38 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | CASP3 | P42574 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.35 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.35 |
| ▸ | CSF1R | P07333 | 1/20 | 0.34 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.34 |
| ▸ | LTA4H | P09960 | 1/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 4/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.33 |
| ▸ | HTR1A | P08908 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6226029 | 0.87 | ADRA1D (0.38) | ADRA1DADRA1AADRA1BCSF1RGPR119 | |
| SCHEMBL1673683 | 0.85 | SMN1; SMN2 (0.39) | ADRA1DADRA1AADRA1BMEN1KMT2A | |
| SCHEMBL1674099 | 0.83 | ALDH1A1 (0.39) | ADRA1DADRA1AADRA1BMEN1KMT2A | |
| SCHEMBL1673775 | 0.81 | GPR119 (0.49) | ADRA1DADRA1AADRA1BMEN1KMT2A | |
| SCHEMBL12733700 | 0.81 | GPR119 (0.41) | ADRA1DADRA1AADRA1BKMT2ACSF1R | |
| SCHEMBL1673746 | 0.81 | GPR119 (0.49) | KMT2ACSF1RGPR119MAPTSMN1; SMN2 | |
| SCHEMBL389075 | 0.80 | SMN1; SMN2 (0.40) | MAPTSMN1; SMN2ALDH1A1L3MBTL1LMNA | |
| SCHEMBL1673977 | 0.69 | MAPT (0.52) | MEN1KMT2AGPR119MAPTALDH1A1 | |
| SCHEMBL1673807 | 0.68 | GPR119 (0.44) | GPR119SMN1; SMN2LMNA | |
| SCHEMBL5261361 | 0.68 | MAPT (0.41) | MEN1NPC1KMT2AGPR119MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1606282-A2 | PHENYL- AND PYRIDYLPIPEREIDINYE-DERIVATIVES AS MODULATORS OF GLUCOSE METABOLISM | Arena Pharmaceuticals, Inc. (US) | 2005-12-21 | — | — | EP | disclosed |
| WO-2004076413-A2 | PHENYL- AND PYRIDYLPIPERIDINE-DERIVATIVES AS MODULATORS OF GLUCOSE METABOLISM | ARENA PHARMACEUTICALS, INC. (US) | 2004-09-10 | — | — | WO | disclosed |