Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | CES2 | O00748 | 1/20 | 0.43 |
| ▸ | CES1 | P23141 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | DAO | P14920 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | APLNR | P35414 | 1/20 | 0.41 |
| ▸ | BCHE | P06276 | 1/20 | 0.41 |
| ▸ | HPGDS | O60760 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.40 |
| ▸ | WNT3A | P56704 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27555554 | 0.84 | KMT2A (0.53) | TP53L3MBTL1KCNA5MAPTALDH1A1 | |
| SCHEMBL6207878 | 0.81 | CTNNB1 (0.47) | TP53KCNA5MAPTALDH1A1TDP1 | |
| SCHEMBL2947498 | 0.77 | PTK2B (0.51) | TP53MAPTALDH1A1TDP1CES2 | |
| SCHEMBL7702480 | 0.75 | CES2 (0.50) | TP53L3MBTL1MAPTALDH1A1TDP1 | |
| 1,2-Dichlorobenzene SCHEMBL29114306 | 0.74 | DAO (0.76) | TP53L3MBTL1MAPTALDH1A1TDP1 | |
| SCHEMBL8157515 | 0.74 | KMT2A (0.49) | TP53L3MBTL1KCNA5MAPTALDH1A1 | |
| SCHEMBL964110 | 0.73 | ELANE (0.49) | TP53MAPTALDH1A1TDP1ATM | |
| SCHEMBL9661038 | 0.73 | BCHE (0.47) | TP53MAPTTDP1CES2CES1 | |
| SCHEMBL4365440 | 0.72 | CES2 (0.56) | TP53L3MBTL1MAPTALDH1A1TDP1 | |
| SCHEMBL9510682 | 0.71 | CES2 (0.46) | TP53MAPTALDH1A1TDP1CES2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1532128-A1 | INHIBITORS OF HCV NS5B POLYMERASE | Pharmacia & Upjohn Company LLC (US) | 2005-05-25 | — | — | EP | disclosed |
| WO-2004002977-A1 | INHIBITORS OF HCV NS5B POLYMERASE | PHARMACIA & UPJOHN COMPANY LLC (US) | 2004-01-08 | — | — | WO | disclosed |