Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTNNB1 | P35222 | 2/20 | 0.47 |
| ▸ | WNT3A | P56704 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | APLNR | P35414 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | CES2 | O00748 | 1/20 | 0.43 |
| ▸ | CES1 | P23141 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6206232 | 0.81 | TP53 (0.47) | CTNNB1WNT3ATDP1ATMKCNA5 | |
| SCHEMBL8157515 | 0.80 | KMT2A (0.49) | TDP1KCNA5PKMMAPTSMN1; SMN2 | |
| SCHEMBL7702480 | 0.78 | CES2 (0.50) | CTNNB1WNT3ATDP1APLNRMAPT | |
| SCHEMBL8969122 | 0.78 | TSHR (0.51) | CTNNB1WNT3ATDP1MAPTSMN1; SMN2 | |
| SCHEMBL7064558 | 0.77 | TDP1 (0.50) | TDP1ATMMAPTSMN1; SMN2MEN1 | |
| SCHEMBL650229 | 0.74 | ELANE (0.50) | TDP1ATMSMN1; SMN2HPGDMEN1 | |
| SCHEMBL27304194 | 0.73 | APLNR (0.46) | CTNNB1WNT3ATDP1APLNRMAPT | |
| SCHEMBL10779676 | 0.73 | BCHE (0.47) | TDP1ATMMAPTSMN1; SMN2MEN1 | |
| SCHEMBL28196633 | 0.73 | ATM (0.44) | TDP1ATMMAPTMEN1ALDH1A1 | |
| SCHEMBL2445884 | 0.72 | ALDH1A1 (0.46) | TDP1ATMMAPTSMN1; SMN2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1532128-A1 | INHIBITORS OF HCV NS5B POLYMERASE | Pharmacia & Upjohn Company LLC (US) | 2005-05-25 | — | — | EP | disclosed |
| WO-2004002977-A1 | INHIBITORS OF HCV NS5B POLYMERASE | PHARMACIA & UPJOHN COMPANY LLC (US) | 2004-01-08 | — | — | WO | disclosed |