Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.40 |
| ▸ | CASP6 | P55212 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | ELANE | P08246 | 1/20 | 0.39 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.39 |
| ▸ | FEN1 | P39748 | 1/20 | 0.39 |
| ▸ | APLNR | P35414 | 1/20 | 0.38 |
| ▸ | IMPDH2 | P12268 | 3/20 | 0.38 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.38 |
| ▸ | DHODH | Q02127 | 1/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.37 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.36 |
| ▸ | IMPDH1 | P20839 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2122983 | 0.73 | BTK (0.44) | BTKNPC1RAB9AHRH4CA1 | |
| SCHEMBL16481976 | 0.71 | BTK (0.42) | BTKNPC1RAB9AHRH4CA1 | |
| SCHEMBL2121707 | 0.71 | BTK (0.42) | BTKNPC1RAB9AHRH4CA1 | |
| SCHEMBL27172748 | 0.71 | IMPDH2 (0.39) | NPC1RAB9AALOX5APFEN1IMPDH2 | |
| SCHEMBL26259970 | 0.70 | SCN9A (0.47) | NPC1CASP6IMPDH2SCN9AIMPDH1 | |
| SCHEMBL20801655 | 0.70 | BTK (0.48) | BTKNPC1RAB9AHRH4CA1 | |
| SCHEMBL12676837 | 0.70 | BTK (0.48) | BTKNPC1RAB9AHRH4CA1 | |
| SCHEMBL22939929 | 0.70 | CCR1 (0.48) | BTKNPC1RAB9AHRH4ELANE | |
| SCHEMBL22940967 | 0.70 | RAB9A (0.47) | BTKNPC1RAB9AHRH4CASP6 | |
| SCHEMBL15344911 | 0.70 | CCR1 (0.52) | BTKNPC1RAB9AHRH4ELANE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1583749-A1 | OXAZOLE DERIVATIVES AS INHIBITORS OF CYCLOOXYGENASE | Astellas Pharma Inc. (JP) | 2005-10-12 | — | — | EP | disclosed |
| WO-2004065374-A1 | OXAZOLE DERIVATIVES AS INHIBITORS OF CYCLOOXYGENASE | ASTELLAS PHARMA INC. (JP) | 2004-08-05 | — | — | WO | disclosed |