Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | XDH | P47989 | 1/20 | 0.71 |
| ▸ | RAB9A | P51151 | 11/20 | 0.63 |
| ▸ | NPC1 | O15118 | 10/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.63 |
| ▸ | TP53 | P04637 | 9/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 9/20 | 0.63 |
| ▸ | MAPT | P10636 | 9/20 | 0.63 |
| ▸ | HPGD | P15428 | 7/20 | 0.63 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.63 |
| ▸ | LMNA | P02545 | 3/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.62 |
| ▸ | MITF | O75030 | 1/20 | 0.62 |
| ▸ | PKM | P14618 | 1/20 | 0.62 |
| ▸ | HTT | P42858 | 1/20 | 0.62 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.62 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.62 |
| ▸ | MEN1 | O00255 | 3/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.60 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6206486 | 0.85 | GSK3B (0.60) | RAB9ANPC1KDM4ESMN1; SMN2MAPT | |
| SCHEMBL2499455 | 0.83 | XDH (0.71) | XDHRAB9ANPC1KDM4ETP53 | |
| SCHEMBL31337054 | 0.80 | ALDH1A1 (0.67) | XDHRAB9ANPC1KDM4ETP53 | |
| SCHEMBL6282033 | 0.80 | ALDH1A1 (0.67) | XDHRAB9ANPC1KDM4ETP53 | |
| SCHEMBL13087861 | 0.80 | SMN1; SMN2 (0.55) | XDHRAB9ANPC1KDM4ETP53 | |
| SCHEMBL6206370 | 0.80 | KDM4E (0.73) | XDHRAB9ANPC1KDM4ETP53 | |
| SCHEMBL1353900 | 0.79 | SMN1; SMN2 (0.54) | XDHRAB9ANPC1KDM4ETP53 | |
| SCHEMBL1245386 | 0.78 | GPR119 (0.52) | XDHLMNAALDH1A1 | |
| SCHEMBL1355636 | 0.76 | SMN1; SMN2 (0.51) | XDHRAB9ANPC1KDM4ETP53 | |
| SCHEMBL10016528 | 0.76 | RAB9A (1.00) | RAB9ANPC1KDM4ETP53SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1551841-A1 | PYRAZOLOPYRIMIDINES AS KINASE INHIBITORS | SmithKline Beecham Corporation (US) | 2005-07-13 | — | — | EP | disclosed |
| WO-2004009602-A1 | PYRAZOLOPYRIMIDINES AS KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2004-01-29 | — | — | WO | disclosed |
| WO-2004009602-A1 | PYRAZOLOPYRIMIDINES AS KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2004-01-29 | — | — | WO | disclosed |