Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NISCH | Q9Y2I1 | 14/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | RECQL | P46063 | 1/20 | 0.49 |
| ▸ | MAOB | P27338 | 2/20 | 0.44 |
| ▸ | MAOA | P21397 | 1/20 | 0.44 |
| ▸ | HTR1D | P28221 | 1/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6253725 | 0.83 | NISCH (0.61) | NISCHMAOBHTR1DADRA1A | |
| SCHEMBL2242209 | 0.76 | NISCH (0.68) | NISCHLMNARECQLMAOBMAOA | |
| SCHEMBL5125909 | 0.76 | NISCH (0.51) | NISCHLMNARECQL | |
| SCHEMBL5125919 | 0.76 | NISCH (0.51) | NISCHLMNARECQL | |
| Hydrochloric Acid SCHEMBL2238276 | 0.75 | NISCH (0.66) | NISCHLMNARECQLMAOBMAOA | |
| Hydrochloric Acid SCHEMBL15514136 | 0.75 | NISCH (0.66) | NISCHLMNARECQLMAOBMAOA | |
| Hydrochloric Acid SCHEMBL2240002 | 0.75 | NISCH (0.66) | NISCHLMNARECQLMAOBMAOA | |
| SCHEMBL4028424 | 0.71 | PTGS2 (0.38) | — | |
| SCHEMBL21672911 | 0.70 | NISCH (0.57) | NISCHHTR1DADRA1A | |
| SCHEMBL5476725 | 0.69 | NISCH (0.79) | NISCHLMNARECQLHTR1DADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1521744-A1 | ARYLSULPHONAMIDE DERIVATIVES AND USE THEREOF AS B1 BRADYKININ RECEPTOR ANTAGONISTS | LABORATOIRES FOURNIER S.A. (FR) | 2005-04-13 | — | — | EP | disclosed |
| WO-2003106428-A1 | NOVEL ARYLSULPHONAMIDE DERIVATIVES AND USE THEREOF AS THERAPEUTIC AGENTS | LABORATOIRES FOURNIER SA (FR) | 2003-12-24 | — | — | WO | disclosed |