Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 4/20 | 0.55 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.55 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.55 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.55 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.55 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.55 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.55 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.55 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.55 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.55 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.55 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | PLAAT3 | P53816 | 5/20 | 0.51 |
| ▸ | PLAAT5 | Q96KN8 | 5/20 | 0.51 |
| ▸ | PLAAT2 | Q9NWW9 | 5/20 | 0.51 |
| ▸ | PLAAT4 | Q9UL19 | 5/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6206996 | 0.90 | KEAP1 (0.52) | HDAC1HDAC3HDAC2HDAC8HDAC6 | |
| SCHEMBL4320328 | 0.83 | HDAC1 (0.58) | HDAC1HDAC3HDAC2HDAC8HDAC6 | |
| SCHEMBL4320330 | 0.83 | HDAC1 (0.58) | HDAC1HDAC3HDAC2HDAC8HDAC6 | |
| SCHEMBL7859 | 0.78 | HDAC1 (0.72) | HDAC1HDAC3HDAC2HDAC8HDAC6 | |
| SCHEMBL6206596 | 0.77 | HDAC1 (0.55) | HDAC1HDAC3HDAC2HDAC8HDAC6 | |
| Hydrochloric Acid SCHEMBL23062929 | 0.76 | HDAC1 (0.69) | HDAC1HDAC3HDAC2HDAC8HDAC6 | |
| SCHEMBL710419 | 0.76 | HDAC1 (0.69) | HDAC1HDAC3HDAC2HDAC8HDAC6 | |
| Hydrochloric Acid SCHEMBL30882658 | 0.76 | HDAC1 (0.69) | HDAC1HDAC3HDAC2HDAC8HDAC6 | |
| SCHEMBL5566614 | 0.76 | HDAC1 (0.69) | HDAC1HDAC3HDAC2HDAC8HDAC6 | |
| Hydrochloric Acid SCHEMBL30882401 | 0.76 | HDAC1 (0.69) | HDAC1HDAC3HDAC2HDAC8HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1532128-A1 | INHIBITORS OF HCV NS5B POLYMERASE | Pharmacia & Upjohn Company LLC (US) | 2005-05-25 | — | — | EP | disclosed |
| WO-2004002977-A1 | INHIBITORS OF HCV NS5B POLYMERASE | PHARMACIA & UPJOHN COMPANY LLC (US) | 2004-01-08 | — | — | WO | disclosed |