Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.48 |
| ▸ | F2 | P00734 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | MIF | P14174 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | FAAH | O00519 | 2/20 | 0.43 |
| ▸ | CES1 | P23141 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | HSF1 | Q00613 | 4/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14562892 | 0.92 | HSF1 (0.44) | MAPTALDH1A1KMT2AHSD17B10F2 | |
| SCHEMBL3956437 | 0.87 | FAAH (0.59) | MAPTALDH1A1KMT2AHSD17B10TP53 | |
| SCHEMBL27267864 | 0.85 | MAPT (0.46) | MAPTALDH1A1LMNATP53HSF1 | |
| SCHEMBL23848115 | 0.84 | MAPT (0.42) | MAPTALDH1A1KMT2AHSD17B10F2 | |
| SCHEMBL27996129 | 0.84 | MAPT (0.42) | MAPTALDH1A1KMT2AHSD17B10F2 | |
| SCHEMBL6462957 | 0.84 | MAPT (0.41) | MAPTALDH1A1KMT2AHSD17B10F2 | |
| SCHEMBL6462954 | 0.84 | MAPT (0.41) | MAPTALDH1A1KMT2AHSD17B10F2 | |
| SCHEMBL3030433 | 0.83 | CNR2 (0.43) | MAPTALDH1A1KMT2AHSD17B10F2 | |
| Hydrochloric Acid SCHEMBL3621160 | 0.83 | LOXL2 (0.47) | MAPTALDH1A1KMT2AHSD17B10F2 | |
| SCHEMBL24928637 | 0.83 | LOXL2 (0.47) | MAPTALDH1A1KMT2AHSD17B10F2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1515726-A1 | MORPHOLINE AND TETRAHYDROPYRAN DERIVATIVES AND THEIR USE AS CATHEPSIN INHIBITORS | Aventis Pharmaceuticals, Inc. (US) | 2005-03-23 | — | — | EP | disclosed |
| WO-2004002491-A1 | MORPHOLINE AND TETRAHYDROPYRAN DRIVATIVES AND THEIR USE AS CATHEPSIN INHIBITORS | AVENTIS PHARMACEUTICALS INC. (US) | 2004-01-08 | — | — | WO | disclosed |