Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 13/20 | 0.49 |
| ▸ | CES1 | P23141 | 12/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | PARP1 | P09874 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | FBP1 | P09467 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6206779 | 1.00 | CES2 (0.49) | CES2CES1TSHRL3MBTL1POLB | |
| SCHEMBL6206793 | 0.86 | CES2 (0.49) | CES2CES1TSHRL3MBTL1POLB | |
| SCHEMBL28789945 | 0.77 | CES2 (0.46) | CES2CES1TSHRL3MBTL1POLB | |
| SCHEMBL6832635 | 0.76 | CES2 (0.44) | CES2CES1TSHRL3MBTL1POLB | |
| SCHEMBL6832632 | 0.76 | CES2 (0.44) | CES2CES1TSHRL3MBTL1POLB | |
| SCHEMBL1174501 | 0.76 | ALDH1A1 (0.44) | CES2CES1TSHRL3MBTL1POLB | |
| SCHEMBL10433272 | 0.75 | TSHR (0.42) | CES2CES1TSHRL3MBTL1POLB | |
| SCHEMBL6206783 | 0.75 | CES2 (0.49) | CES2CES1TSHRL3MBTL1POLB | |
| SCHEMBL10433270 | 0.75 | TSHR (0.42) | CES2CES1TSHRL3MBTL1POLB | |
| SCHEMBL6207820 | 0.72 | CES2 (0.56) | CES2CES1TSHRL3MBTL1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1532128-A1 | INHIBITORS OF HCV NS5B POLYMERASE | Pharmacia & Upjohn Company LLC (US) | 2005-05-25 | — | — | EP | disclosed |
| WO-2004002977-A1 | INHIBITORS OF HCV NS5B POLYMERASE | PHARMACIA & UPJOHN COMPANY LLC (US) | 2004-01-08 | — | — | WO | disclosed |