SCHEMBL6832632

SCHEMBL6832632

O=C(O)/C(=C(/C(=O)O)[N+](=O)[O-])c1ccccc1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CES2 O00748 3/20 0.44
CES1 P23141 3/20 0.44
PRMT1 Q99873 1/20 0.43
CA2 P00918 2/20 0.40
CA4 P22748 2/20 0.40
MAOB P27338 2/20 0.40
BCHE P06276 1/20 0.40
PTPN1 P18031 1/20 0.39
ERCC5 P28715 1/20 0.39
FEN1 P39748 1/20 0.39
TSHR P16473 2/20 0.39
ALDH1A1 P00352 2/20 0.39
DAO P14920 1/20 0.39
NAPRT Q6XQN6 1/20 0.39
TP53 P04637 1/20 0.39
POLB P06746 3/20 0.39
MEN1 O00255 1/20 0.39
NPC1 O15118 1/20 0.39
MITF O75030 1/20 0.39
RAB9A P51151 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6832635 1.00 CES2 (0.44) CES2CES1PRMT1CA2CA4
SCHEMBL10433270 0.87 TSHR (0.42) CES2CES1PRMT1CA2CA4
SCHEMBL10433272 0.87 TSHR (0.42) CES2CES1PRMT1CA2CA4
SCHEMBL28789945 0.82 CES2 (0.46) CES2CES1PRMT1CA2CA4
SCHEMBL2184443 0.80 ALDH1A1 (0.44) CES2CES1PRMT1CA2CA4
SCHEMBL1174501 0.80 ALDH1A1 (0.44) CES2CES1PRMT1CA2CA4
SCHEMBL6206779 0.76 CES2 (0.49) CES2CES1PRMT1TSHRALDH1A1
SCHEMBL6206786 0.76 CES2 (0.49) CES2CES1PRMT1TSHRALDH1A1
SCHEMBL523842 0.75 CES1 (0.58) CES2CES1CA2CA4PTPN1
SCHEMBL114583 0.75 CES1 (0.58) CES2CES1CA2CA4PTPN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2841422-A1 METHODS FOR THE SYNTHESIS OF ETHYLFUMARATES AND THEIR USE AS INTERMEDIATES Mannkind Corporation (US) 2015-03-04 EP disclosed
WO-2013162764-A1 METHODS FOR THE SYNTHESIS OF ETHYLFUMARATES AND THEIR USE AS INTERMEDIATES MANNKIND CORP (US) 2013-10-31 WO disclosed
EP-1456226-A1 SITE SELECTIVE ACYLATION ModPro AB (SE) 2004-09-15 EP disclosed
WO-2003044042-A1 SITE SELECTIVE ACYLATION MODPRO AB (SE) 2003-05-30 WO disclosed
EP-0952980-A1 ACYL TRANSFER WITH STABILISED TRANSITION COMPLEX USING CATALYST WITH CATALYTIC IMIDAZOLE (E.G. HISTIDINE) FUNCTION A+Science Invest AB (SE) 1999-11-03 EP disclosed
WO-1997043302-A9 ACYL TRANSFER WITH STABILISED TRANSITION COMPLEX USING CATALYST WITH CATALYTIC IMIDAZOLE (E.G. HISTIDINE) FUNCTION 1998-12-23 WO disclosed
WO-1997043302-A1 ACYL TRANSFER WITH STABILISED TRANSITION COMPLEX USING CATALYST WITH CATALYTIC IMIDAZOLE (E.G. HISTIDINE) FUNCTION A+SCIENCE INVEST AB (SE) 1997-11-20 WO disclosed