Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC7 | O00311 | 6/20 | 0.45 |
| ▸ | CCNE1 | P24864 | 6/20 | 0.45 |
| ▸ | CDK2 | P24941 | 6/20 | 0.45 |
| ▸ | DBF4 | Q9UBU7 | 6/20 | 0.45 |
| ▸ | TUBB4A | P04350 | 12/20 | 0.42 |
| ▸ | TUBB | P07437 | 12/20 | 0.42 |
| ▸ | TUBA3C | P0DPH7 | 12/20 | 0.42 |
| ▸ | TUBA1B | P68363 | 12/20 | 0.42 |
| ▸ | TUBA4A | P68366 | 12/20 | 0.42 |
| ▸ | TUBB4B | P68371 | 12/20 | 0.42 |
| ▸ | TUBB3 | Q13509 | 12/20 | 0.42 |
| ▸ | TUBB2A | Q13885 | 12/20 | 0.42 |
| ▸ | TUBB8 | Q3ZCM7 | 12/20 | 0.42 |
| ▸ | TUBA3E | Q6PEY2 | 12/20 | 0.42 |
| ▸ | TUBA1A | Q71U36 | 12/20 | 0.42 |
| ▸ | TUBA1C | Q9BQE3 | 12/20 | 0.42 |
| ▸ | TUBB6 | Q9BUF5 | 12/20 | 0.42 |
| ▸ | TUBB2B | Q9BVA1 | 12/20 | 0.42 |
| ▸ | TUBB1 | Q9H4B7 | 12/20 | 0.42 |
| ▸ | TRPC5 | Q9UL62 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6406191 | 0.91 | ALDH1A1 (0.38) | CDC7CCNE1CDK2DBF4TUBB4A | |
| SCHEMBL6399621 | 0.85 | KDR (0.46) | CDC7CCNE1CDK2DBF4TUBB4A | |
| SCHEMBL6399213 | 0.85 | LMNA (0.34) | CDC7CCNE1CDK2DBF4TUBB4A | |
| SCHEMBL6208644 | 0.84 | CDC7 (0.46) | CDC7CCNE1CDK2DBF4TUBB4A | |
| SCHEMBL6207603 | 0.84 | CDC7 (0.38) | CDC7CCNE1CDK2DBF4TUBB4A | |
| SCHEMBL6398977 | 0.83 | KDR (0.34) | CDC7CCNE1CDK2DBF4TUBB4A | |
| SCHEMBL6206308 | 0.83 | TRPC5 (0.37) | CDC7CCNE1CDK2DBF4TUBB4A | |
| SCHEMBL6207571 | 0.83 | TRPC5 (0.40) | CDC7CCNE1CDK2DBF4TUBB4A | |
| SCHEMBL6400416 | 0.83 | KDM4E (0.35) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL6209514 | 0.83 | TRPC5 (0.38) | CDC7CCNE1CDK2DBF4TUBB4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1578736-A1 | MEK INHIBITING OXA- AND THIA-DIAZOL-2-YL-PHENYLAMINE DERIVATIVES | Warner-Lambert Company LLC (US) | 2005-09-28 | — | — | EP | claimed |
| US-20050004186-A1 | MEK inhibiting compounds | PFIZER INC | 2005-01-06 | — | — | US | claimed |
| WO-2004056789-A1 | MEK INHIBITING OXA- AND THIA-DIAZOL-2-YL PHENYLAMINE DERIVATES | WARNER-LAMBERT COMPANY LLC (US) | 2004-07-08 | — | — | WO | claimed |
| EP-1578736-A1 | MEK INHIBITING OXA- AND THIA-DIAZOL-2-YL-PHENYLAMINE DERIVATIVES | Warner-Lambert Company LLC (US) | 2005-09-28 | — | — | EP | disclosed |
| US-20050004186-A1 | MEK inhibiting compounds | PFIZER INC | 2005-01-06 | — | — | US | disclosed |
| WO-2004056789-A1 | MEK INHIBITING OXA- AND THIA-DIAZOL-2-YL PHENYLAMINE DERIVATES | WARNER-LAMBERT COMPANY LLC (US) | 2004-07-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050004186-A1 | MEK inhibiting compounds | MAPK1, MAP3K1, MAPK3 | CDC7 395/4885CCNE1 983/4885CDK2 110/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.