Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 13/20 | 0.72 |
| ▸ | BRAF | P15056 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 3/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4248593 | 0.84 | RAF1 (1.00) | RAF1BRAFMAPTKDM4E | |
| SCHEMBL618105 | 0.80 | RAF1 (1.00) | RAF1BRAFMAPK1MEN1KMT2A | |
| SCHEMBL939567 | 0.80 | RAF1 (1.00) | RAF1BRAFMAPTKDM4EMAPK1 | |
| SCHEMBL4243486 | 0.80 | RAF1 (0.61) | RAF1BRAFMAPTMAPK1MEN1 | |
| SCHEMBL938321 | 0.80 | RAF1 (0.74) | RAF1BRAFMAPTKDM4E | |
| SCHEMBL617631 | 0.79 | RAF1 (0.65) | RAF1BRAFMAPTMAPK1MEN1 | |
| SCHEMBL13265973 | 0.78 | RAB9A (0.74) | MAPTKDM4EMAPK1RXFP1MEN1 | |
| SCHEMBL16782003 | 0.78 | MAPT (0.70) | RAF1BRAFMAPTKDM4EMAPK1 | |
| SCHEMBL3476076 | 0.78 | RAF1 (0.61) | RAF1BRAFMAPTMAPK1MEN1 | |
| SCHEMBL4247303 | 0.78 | MEN1 (0.64) | RAF1BRAFMAPTKDM4EMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1042305-B1 | INHIBITION OF p38 KINASE USING SYMMETRICAL AND UNSYMMETRICAL DIPHENYL UREAS | BAYER PHARMACEUTICALS CORP (US) | 2005-06-08 | — | — | EP | claimed |