Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 17/20 | 0.52 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.41 |
| ▸ | GRM5 | P41594 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | NSD2 | O96028 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11177396 | 0.81 | PTGS2 (0.74) | PTGS2PTGS1 | |
| SCHEMBL6207136 | 0.79 | PTGS2 (0.36) | PTGS2PTGS1KDM4ENSD2MAPT | |
| SCHEMBL13198633 | 0.79 | PTGS2 (0.82) | PTGS2PTGS1 | |
| SCHEMBL11181698 | 0.78 | CASP1 (0.45) | PTGS2GRM5KDM4ENSD2MAPT | |
| SCHEMBL11387173 | 0.73 | PDE7A (0.52) | PTGS2GRM5MAPTMAPK1 | |
| SCHEMBL10789247 | 0.71 | MAPT (0.46) | PTGS2PTGS1KDM4ENSD2MAPT | |
| SCHEMBL6205230 | 0.70 | PTGS2 (0.44) | PTGS2PTGS1 | |
| SCHEMBL316294 | 0.70 | GRM5 (0.54) | PTGS2GRM5 | |
| SCHEMBL8925113 | 0.67 | CA12 (0.45) | — | |
| SCHEMBL16738811 | 0.66 | MAPT (0.53) | PTGS2GRM5KDM4ENSD2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1098891-B1 | POLYCYCLIC THIAZOLIDIN-2-YLIDENE AMINES, METHOD FOR THE PRODUCTION AND USE THEREOF AS MEDICAMENTS | AVENTIS PHARMA GMBH (DE) | 2005-08-10 | — | — | EP | disclosed |
| EP-1098891-A1 | POLYCYCLIC THIAZOLIDIN-2-YLIDENE AMINES, METHOD FOR THE PRODUCTION AND USE THEREOF AS MEDICAMENTS | Aventis Pharma Deutschland GmbH (DE) | 2001-05-16 | — | — | EP | disclosed |
| US-6159996-A | Polycyclic thiazolidin-2-ylidene amines, process for their preparation, and their use as pharmaceuticals | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2000-12-12 | — | — | US | disclosed |
| WO-2000004006-A1 | POLYCYCLIC THIAZOLIDIN-2-YLIDENE AMINES, METHOD FOR THE PRODUCTION AND USE THEREOF AS MEDICAMENTS | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2000-01-27 | — | — | WO | disclosed |