Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 15/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 5/20 | 0.44 |
| ▸ | CASP1 | P29466 | 1/20 | 0.42 |
| ▸ | CASP7 | P55210 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6206319 | 0.84 | PTGS2 (0.39) | PTGS2PTGS1CASP1CASP7HSD17B10 | |
| SCHEMBL11660830 | 0.82 | CA1 (0.47) | PTGS2PTGS1CASP1CASP7HSD17B10 | |
| SCHEMBL31591225 | 0.78 | PBRM1 (0.47) | PTGS2PTGS1CASP1CASP7HSD17B10 | |
| SCHEMBL1512735 | 0.78 | PBRM1 (0.47) | PTGS2PTGS1CASP1CASP7HSD17B10 | |
| SCHEMBL2907226 | 0.76 | PBRM1 (0.41) | PTGS2PTGS1CASP1CASP7HSD17B10 | |
| SCHEMBL11659662 | 0.76 | L3MBTL1 (0.43) | PTGS2PTGS1L3MBTL1 | |
| SCHEMBL6205822 | 0.72 | L3MBTL1 (0.33) | PTGS2PTGS1L3MBTL1 | |
| SCHEMBL21962019 | 0.72 | PBRM1 (0.41) | PTGS2PTGS1CASP1CASP7HSD17B10 | |
| SCHEMBL2914485 | 0.72 | PBRM1 (0.41) | PTGS2PTGS1CASP1CASP7HSD17B10 | |
| SCHEMBL31511760 | 0.72 | PBRM1 (0.41) | PTGS2PTGS1CASP1CASP7HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1098891-B1 | POLYCYCLIC THIAZOLIDIN-2-YLIDENE AMINES, METHOD FOR THE PRODUCTION AND USE THEREOF AS MEDICAMENTS | AVENTIS PHARMA GMBH (DE) | 2005-08-10 | — | — | EP | disclosed |
| EP-1098891-A1 | POLYCYCLIC THIAZOLIDIN-2-YLIDENE AMINES, METHOD FOR THE PRODUCTION AND USE THEREOF AS MEDICAMENTS | Aventis Pharma Deutschland GmbH (DE) | 2001-05-16 | — | — | EP | disclosed |
| US-6159996-A | Polycyclic thiazolidin-2-ylidene amines, process for their preparation, and their use as pharmaceuticals | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2000-12-12 | — | — | US | disclosed |
| WO-2000004006-A1 | POLYCYCLIC THIAZOLIDIN-2-YLIDENE AMINES, METHOD FOR THE PRODUCTION AND USE THEREOF AS MEDICAMENTS | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2000-01-27 | — | — | WO | disclosed |