Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR9 | P51686 | 3/20 | 0.44 |
| ▸ | SLC40A1 | Q9NP59 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | NAMPT | P43490 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6224943 | 0.92 | CCR9 (0.46) | CCR9NAMPTMAPTKMT2ACYP2C9 | |
| SCHEMBL6177182 | 0.89 | ALDH1A1 (0.36) | CCR9SMN1; SMN2NAMPTALDH1A1TP53 | |
| SCHEMBL6173837 | 0.89 | LIPE (0.38) | CCR9ALDH1A1KDM4ECYP3A4GAA | |
| SCHEMBL6173098 | 0.88 | FLT1 (0.36) | CCR9NAMPTALDH1A1KDM4ELMNA | |
| SCHEMBL6175495 | 0.87 | CYP3A4 (0.36) | CCR9NAMPTMAPTALDH1A1KMT2A | |
| SCHEMBL6173018 | 0.87 | CCR9 (0.37) | CCR9SMN1; SMN2MAPTALDH1A1KDM4E | |
| SCHEMBL6176637 | 0.87 | IGF1R (0.40) | SMN1; SMN2ALDH1A1KDM4ELMNATP53 | |
| SCHEMBL6173183 | 0.85 | CYP3A4 (0.39) | CCR9ALDH1A1CYP3A4GAACYP2C9 | |
| SCHEMBL6173294 | 0.84 | CYP3A4 (0.38) | CCR9ALDH1A1CYP3A4GAACYP2C9 | |
| SCHEMBL6176657 | 0.83 | CYP3A4 (0.40) | NAMPTALDH1A1CYP3A4GAACYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599464-A2 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2005-11-30 | — | — | EP | disclosed |
| WO-2004070050-A2 | CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2004-08-19 | — | — | WO | disclosed |