Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 7/20 | 0.36 |
| ▸ | FPR3 | P25089 | 1/20 | 0.36 |
| ▸ | FPR2 | P25090 | 1/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | CTSS | P25774 | 4/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | CTSL | P07711 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | AR | P10275 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4700452 | 1.00 | CTSK (0.36) | CTSKFPR3FPR2P2RX7SMN1; SMN2 | |
| SCHEMBL4755888 | 0.85 | BRD4 (0.38) | CTSKCTSSBRD4CTSL | |
| SCHEMBL4701812 | 0.85 | BRD4 (0.38) | CTSKCTSSBRD4CTSL | |
| SCHEMBL4703433 | 0.84 | CTSS (0.42) | CTSKP2RX7CTSSCTSL | |
| SCHEMBL4700861 | 0.83 | P2RX7 (0.39) | CTSKP2RX7CTSS | |
| SCHEMBL4699857 | 0.83 | BRD4 (0.36) | CTSKP2RX7CTSSBRD4CTSL | |
| SCHEMBL4704142 | 0.82 | CTSK (0.41) | CTSKCTSSCTSL | |
| SCHEMBL4699988 | 0.82 | P2RX7 (0.34) | CTSKP2RX7SMN1; SMN2L3MBTL1CTSS | |
| SCHEMBL4701637 | 0.82 | CTSK (0.41) | CTSKFPR3FPR2P2RX7SMN1; SMN2 | |
| SCHEMBL4698830 | 0.81 | CTSK (0.40) | CTSKCTSSKDM4EBRD4CTSL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1372655-A4 | CATHEPSIN CYSTEINE PROTEASE INHIBITORS | MERCK FROSST CANADA INC (CA) | 2005-10-12 | — | — | EP | claimed |
| EP-1372655-A2 | CATHEPSIN CYSTEINE PROTEASE INHIBITORS | Merck Frosst Canada & Co. (CA) | 2004-01-02 | — | — | EP | claimed |
| WO-2002069901-A2 | CATHEPSIN CYSTEINE PROTEASE INHIBITORS | MERCK FROSST CANADA & CO. (CA) | 2002-09-12 | — | — | WO | claimed |