Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | CTSA | P10619 | 9/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | FAAH | O00519 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5201378 | 0.89 | L3MBTL1 (0.54) | L3MBTL1PKMCTSASMN1; SMN2NPC1 | |
| SCHEMBL2464521 | 0.77 | L3MBTL1 (0.41) | L3MBTL1SMN1; SMN2NPC1RAB9ATSHR | |
| SCHEMBL5086318 | 0.76 | FAAH (0.45) | L3MBTL1CTSASMN1; SMN2NPC1RAB9A | |
| SCHEMBL3663114 | 0.76 | L3MBTL1 (0.43) | L3MBTL1SMN1; SMN2NPC1RAB9ATSHR | |
| SCHEMBL21552119 | 0.75 | CTSA (0.45) | CTSA | |
| SCHEMBL21552487 | 0.75 | CTSA (0.47) | CTSA | |
| SCHEMBL5504022 | 0.75 | SMN1; SMN2 (0.42) | L3MBTL1SMN1; SMN2NPC1RAB9ATSHR | |
| SCHEMBL14040614 | 0.75 | SMN1; SMN2 (0.57) | L3MBTL1SMN1; SMN2NPC1RAB9ATSHR | |
| SCHEMBL844472 | 0.75 | SMN1; SMN2 (0.57) | L3MBTL1SMN1; SMN2NPC1RAB9ATSHR | |
| SCHEMBL6207414 | 0.74 | L3MBTL1 (0.55) | L3MBTL1PKMSMN1; SMN2RAB9ATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1569954-A1 | CYANOMETHYL DERIVATIVES AS CYSTEINE PROTEASE INHIBITORS | AXYS PHARMACEUTICALS, INC. (US) | 2005-09-07 | — | — | EP | disclosed |
| EP-1503997-A1 | CYSTEINE PROTEASE INHIBITORS | AXYS PHARMACEUTICALS, INC. (US) | 2005-02-09 | — | — | EP | disclosed |
| WO-2004052921-A1 | CYANOMETHYL DERIVATIVES AS CYSTEINE PROTEASE INHIBITORS | AXYS PHARMACEUTICALS, INC. (US) | 2004-06-24 | — | — | WO | disclosed |
| WO-2003097617-A1 | CYSTEINE PROTEASE INHIBITORS | AXYS PHARMACEUTICALS, INC. (US) | 2003-11-27 | — | — | WO | disclosed |