Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 7/20 | 0.58 |
| ▸ | PRKAB2 | O43741 | 5/20 | 0.56 |
| ▸ | PRKAG1 | P54619 | 5/20 | 0.56 |
| ▸ | PRKAA2 | P54646 | 5/20 | 0.56 |
| ▸ | PRKAA1 | Q13131 | 5/20 | 0.56 |
| ▸ | PRKAG3 | Q9UGI9 | 5/20 | 0.56 |
| ▸ | PRKAG2 | Q9UGJ0 | 5/20 | 0.56 |
| ▸ | PRKAB1 | Q9Y478 | 5/20 | 0.56 |
| ▸ | FADS1 | O60427 | 1/20 | 0.55 |
| ▸ | CDK1 | P06493 | 1/20 | 0.53 |
| ▸ | CDK2 | P24941 | 1/20 | 0.53 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.45 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4498877 | 0.99 | PRKAB2 (0.57) | GSK3BPRKAB2PRKAG1PRKAA2PRKAA1 | |
| SCHEMBL4503888 | 0.90 | FADS1 (0.59) | GSK3BPRKAB2PRKAG1PRKAA2PRKAA1 | |
| SCHEMBL4497901 | 0.89 | GSK3B (0.70) | GSK3BPRKAB2PRKAG1PRKAA2PRKAA1 | |
| SCHEMBL4495390 | 0.84 | GSK3B (0.80) | GSK3BPRKAB2PRKAG1PRKAA2PRKAA1 | |
| SCHEMBL4510158 | 0.84 | GSK3B (0.60) | GSK3BPRKAB2PRKAG1PRKAA2PRKAA1 | |
| SCHEMBL4498891 | 0.83 | MAP2K4 (0.57) | GSK3BPRKAB2PRKAG1PRKAA2PRKAA1 | |
| SCHEMBL4496233 | 0.81 | PRKAB2 (0.65) | GSK3BPRKAB2PRKAG1PRKAA2PRKAA1 | |
| SCHEMBL27623023 | 0.81 | MAPK8 (0.56) | GSK3BPRKAB2PRKAG1PRKAA2PRKAA1 | |
| SCHEMBL4498900 | 0.81 | TRPA1 (0.59) | GSK3BPRKAB2PRKAG1PRKAA2PRKAA1 | |
| SCHEMBL4494950 | 0.80 | TRPA1 (0.62) | GSK3BFADS1CDK1CDK2ABCG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1537087-A1 | NOVEL AMINOINDAZOLE DERIVATIVES AS MEDICINES AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | Aventis Pharma S.A. (FR) | 2005-06-08 | — | — | EP | disclosed |
| WO-2004022544-A1 | NOVEL AMINOINDAZOLE DERIVATIVES AS MEDICINES AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | AVENTIS PHARMA S.A. (FR) | 2004-03-18 | — | — | WO | disclosed |