Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | PARP1 | P09874 | 10/20 | 0.50 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.50 |
| ▸ | PIM1 | P11309 | 2/20 | 0.50 |
| ▸ | AKT1 | P31749 | 1/20 | 0.50 |
| ▸ | FLT3 | P36888 | 1/20 | 0.50 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.50 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.50 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.47 |
| ▸ | CA12 | O43570 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | CA9 | Q16790 | 1/20 | 0.47 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.47 |
| ▸ | IP6K1 | Q92551 | 5/20 | 0.46 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.45 |
| ▸ | KDM4A | O75164 | 1/20 | 0.44 |
| ▸ | KDM4B | O94953 | 1/20 | 0.44 |
| ▸ | KDM5C | P41229 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2921734 | 0.77 | PARP1 (0.61) | MKNK1ALDH1A1PARP1CHEK1PIM1 | |
| SCHEMBL29744436 | 0.77 | PARP1 (0.61) | MKNK1ALDH1A1PARP1CHEK1PIM1 | |
| SCHEMBL9313899 | 0.77 | MAPT (0.48) | ALDH1A1SMN1; SMN2 | |
| SCHEMBL13948933 | 0.77 | MKNK1 (0.60) | MKNK1ALDH1A1PARP1CHEK1PIM1 | |
| SCHEMBL11263951 | 0.75 | MKNK1 (1.00) | MKNK1ALDH1A1PARP1CHEK1PIM1 | |
| SCHEMBL9379086 | 0.73 | ALDH1A1 (0.46) | MKNK1ALDH1A1PARP1CHEK1PIM1 | |
| SCHEMBL7076189 | 0.73 | MKNK1 (0.56) | MKNK1ALDH1A1PARP1CHEK1PIM1 | |
| SCHEMBL4498108 | 0.73 | MAPT (0.48) | ALDH1A1 | |
| SCHEMBL29898482 | 0.70 | ALDH1A1 (1.00) | ALDH1A1PARP1CHEK1PIM1AKT1 | |
| SCHEMBL643424 | 0.70 | ALDH1A1 (1.00) | ALDH1A1PARP1CHEK1PIM1AKT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008147852-A1 | KINESIN INHIBITORS | TAIGEN BIOTECHNOLOGY CO., LTD. (TW) | 2008-12-04 | — | — | WO | disclosed |
| EP-0907642-B1 | PHENYLAMINO-SUBSTITUTED TRICYCLIC DERIVATIVES FOR TREATMENT OF HYPERPROLIFERATIVE DISEASES | PFIZER (US) | 2005-11-02 | — | — | EP | disclosed |
| US-6335344-B1 | Phenylamino-substituted tricyclic derivatives for treatment of hyperproliferative diseases | PFIZER INC. | 2002-01-01 | — | — | US | disclosed |