Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXA2R | P21731 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | TBXAS1 | P24557 | 4/20 | 0.43 |
| ▸ | GSTK1 | Q9Y2Q3 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.41 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.41 |
| ▸ | PTGFR | P43088 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27743476 | 0.86 | POLB (0.50) | SMN1; SMN2POLBKMT2AFFAR1 | |
| SCHEMBL9938570 | 0.85 | LMNA (0.49) | SMN1; SMN2POLBTBXAS1FFAR1 | |
| SCHEMBL6542954 | 0.85 | TBXAS1 (0.55) | TBXA2RSMN1; SMN2TBXAS1GSTK1 | |
| SCHEMBL1595937 | 0.85 | TBXAS1 (0.55) | TBXA2RSMN1; SMN2TBXAS1GSTK1 | |
| SCHEMBL14360038 | 0.85 | TBXAS1 (0.55) | TBXA2RSMN1; SMN2TBXAS1GSTK1 | |
| SCHEMBL14359989 | 0.85 | TBXAS1 (0.55) | TBXA2RSMN1; SMN2TBXAS1GSTK1 | |
| SCHEMBL14360466 | 0.85 | TBXAS1 (0.55) | TBXA2RSMN1; SMN2TBXAS1GSTK1 | |
| SCHEMBL28987106 | 0.84 | TBXA2R (0.56) | TBXA2RPOLBTBXAS1GSTK1PTGFR | |
| SCHEMBL27319929 | 0.84 | GSTK1 (0.42) | TBXA2RSMN1; SMN2POLBTBXAS1GSTK1 | |
| SCHEMBL7564104 | 0.83 | TBXAS1 (0.50) | TBXA2RTBXAS1KMT2AFFAR4FFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1564200-A1 | Ketone compounds and compositions for cholesterol management and related uses | Esperion Therapeutics Inc. (US) | 2005-08-17 | — | — | EP | disclosed |
| EP-1326822-A2 | KETONE COMPOUNDS AND COMPOSITIONS FOR CHOLESTEROL MANAGEMENT AND RELATED USES | Esperion Therapeutics Inc. (US) | 2003-07-16 | — | — | EP | disclosed |
| WO-2002030860-A2 | KETONE COMPOUNDS AND COMPOSITIONS FOR CHOLESTEROL MANAGEMENT AND RELATED USES | ESPERION THERAPEUTICS, INC. (US) | 2002-04-18 | — | — | WO | disclosed |