Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
| ▸ | C5 | P01031 | 2/20 | 0.37 |
| ▸ | FPR2 | P25090 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | GNRHR | P30968 | 5/20 | 0.35 |
| ▸ | IDO1 | P14902 | 1/20 | 0.35 |
| ▸ | TDO2 | P48775 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.34 |
| ▸ | IGF1R | P08069 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6205153 | 0.75 | SMN1; SMN2 (0.35) | LMNAALDH1A1MAPTKMT2A | |
| SCHEMBL5795287 | 0.73 | SMN1; SMN2 (0.38) | LMNAKDM4EALDH1A1MEN1MAPT | |
| SCHEMBL5831107 | 0.72 | PTK2 (0.42) | MAPT | |
| SCHEMBL4707388 | 0.69 | MAPK14 (0.35) | LMNAMEN1MAPTKMT2A | |
| SCHEMBL4757853 | 0.69 | MAPK14 (0.35) | LMNAMEN1MAPTKMT2A | |
| SCHEMBL4707014 | 0.69 | MAPK14 (0.35) | LMNAMEN1MAPTKMT2A | |
| SCHEMBL4757107 | 0.69 | MAPK14 (0.35) | LMNAMEN1MAPTKMT2A | |
| SCHEMBL4707017 | 0.69 | MAPK14 (0.35) | LMNAMEN1MAPTKMT2A | |
| SCHEMBL23925527 | 0.64 | LMNA (0.38) | LMNAKDM4EALDH1A1HPGDMEN1 | |
| SCHEMBL15633603 | 0.63 | PIN1 (0.36) | KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1560832-A1 | PYRIMIDO 4,5-D PYRIMIDINE DERIVATIVES WITH ANTICANCER ACTIVITY | F. HOFFMANN-LA ROCHE AG (CH) | 2005-08-10 | — | — | EP | disclosed |
| WO-2004041822-A1 | PYRIMIDO[4,5-D]PYRIMIDINE DERIVATIVES WITH ANTICANCER ACTIVITY | F. HOFFMANN-LA ROCHE AG (CH) | 2004-05-21 | — | — | WO | disclosed |