Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | KIT | P10721 | 2/20 | 0.34 |
| ▸ | ADH1A | P07327 | 1/20 | 0.34 |
| ▸ | FLT1 | P17948 | 1/20 | 0.34 |
| ▸ | FLT4 | P35916 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
| ▸ | ABL2 | P42684 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | DRD3 | P35462 | 1/20 | 0.32 |
| ▸ | CHRM3 | P20309 | 7/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | USP2 | O75604 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6207807 | 1.00 | EPHX2 (0.41) | EPHX2KITADH1AFLT1FLT4 | |
| SCHEMBL6207802 | 0.81 | ADH1A (0.35) | KITADH1AFLT1FLT4KDR | |
| SCHEMBL8097983 | 0.81 | ADH1A (0.41) | KITADH1AFLT1FLT4KDR | |
| SCHEMBL8097976 | 0.81 | ADH1A (0.41) | KITADH1AFLT1FLT4KDR | |
| SCHEMBL16942017 | 0.79 | ADH1A (0.40) | EPHX2KITADH1AFLT1FLT4 | |
| SCHEMBL6205071 | 0.79 | ADH1A (0.40) | EPHX2KITADH1AFLT1FLT4 | |
| SCHEMBL16942012 | 0.78 | ADH1A (0.41) | EPHX2KITADH1AFLT1FLT4 | |
| SCHEMBL6205394 | 0.78 | ADH1A (0.39) | KITADH1AFLT1FLT4KDR | |
| SCHEMBL6205398 | 0.78 | ADH1A (0.39) | KITADH1AFLT1FLT4KDR | |
| SCHEMBL21297107 | 0.76 | ADH1A (0.39) | EPHX2KITADH1AFLT1FLT4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0938474-B1 | CYCLOPROPYLINDOLE COMPOUNDS AND THEIR USE AS PRODRUGS | AUCKLAND UNISERVICES LTD (NZ) | 2005-11-23 | — | — | EP | disclosed |
| US-6130237-A | Condensed N-aclyindoles as antitumor agents | CANCER RESEARCH CAMPAIGN TECHNOLOGY LIMITED (GB) | 2000-10-10 | — | — | US | disclosed |