Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 14/20 | 0.47 |
| ▸ | CTSB | P07858 | 8/20 | 0.42 |
| ▸ | CTSS | P25774 | 8/20 | 0.42 |
| ▸ | CTSL | P07711 | 3/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4704456 | 1.00 | CTSK (0.47) | CTSKCTSBCTSSCTSL | |
| SCHEMBL4704928 | 0.86 | CTSK (0.49) | CTSKCTSBCTSSCTSL | |
| SCHEMBL4699578 | 0.83 | CTSK (0.51) | CTSKCTSBCTSSCTSL | |
| SCHEMBL4699575 | 0.83 | CTSK (0.51) | CTSKCTSBCTSSCTSL | |
| SCHEMBL4703591 | 0.76 | CTSK (0.44) | CTSKCTSBCTSSCTSL | |
| SCHEMBL11983632 | 0.69 | L3MBTL1 (0.43) | — | |
| SCHEMBL4701895 | 0.69 | CTSK (0.53) | CTSKCTSBCTSSCTSL | |
| SCHEMBL4701637 | 0.69 | CTSK (0.41) | CTSKCTSBCTSSCTSL | |
| SCHEMBL4700257 | 0.69 | CTSK (0.43) | CTSKCTSBCTSS | |
| SCHEMBL13310423 | 0.69 | ALDH1A1 (0.47) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1372655-A4 | CATHEPSIN CYSTEINE PROTEASE INHIBITORS | MERCK FROSST CANADA INC (CA) | 2005-10-12 | — | — | EP | claimed |
| EP-1372655-A2 | CATHEPSIN CYSTEINE PROTEASE INHIBITORS | Merck Frosst Canada & Co. (CA) | 2004-01-02 | — | — | EP | claimed |
| WO-2002069901-A2 | CATHEPSIN CYSTEINE PROTEASE INHIBITORS | MERCK FROSST CANADA & CO. (CA) | 2002-09-12 | — | — | WO | claimed |
| EP-1372655-A4 | CATHEPSIN CYSTEINE PROTEASE INHIBITORS | MERCK FROSST CANADA INC (CA) | 2005-10-12 | — | — | EP | disclosed |
| EP-1372655-A2 | CATHEPSIN CYSTEINE PROTEASE INHIBITORS | Merck Frosst Canada & Co. (CA) | 2004-01-02 | — | — | EP | disclosed |
| WO-2002069901-A2 | CATHEPSIN CYSTEINE PROTEASE INHIBITORS | MERCK FROSST CANADA & CO. (CA) | 2002-09-12 | — | — | WO | disclosed |