Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | HPGD | P15428 | 3/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | HTR6 | P50406 | 3/20 | 0.43 |
| ▸ | GABRP | O00591 | 1/20 | 0.43 |
| ▸ | GABRD | O14764 | 1/20 | 0.43 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.43 |
| ▸ | IDO1 | P14902 | 1/20 | 0.43 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.43 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.43 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.43 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.43 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27623557 | 0.77 | KDM4E (0.52) | KDM4EHSD17B10ALDH1A1HPGDTSHR | |
| SCHEMBL8998008 | 0.76 | KDM4E (0.72) | KDM4EHSD17B10ALDH1A1HPGDTSHR | |
| SCHEMBL28785846 | 0.73 | KDM4E (0.55) | KDM4EHSD17B10ALDH1A1HPGDTSHR | |
| SCHEMBL27691174 | 0.73 | KDM4E (0.63) | KDM4EHSD17B10ALDH1A1HPGDTSHR | |
| SCHEMBL28286983 | 0.72 | HTR2A (0.66) | KDM4EHSD17B10ALDH1A1HPGDDRD2 | |
| SCHEMBL28674730 | 0.72 | CHRNB2 (0.59) | KDM4EHSD17B10ALDH1A1HPGDTSHR | |
| SCHEMBL4921978 | 0.71 | KDM4E (0.70) | KDM4EHSD17B10ALDH1A1HPGDTSHR | |
| SCHEMBL28987798 | 0.71 | CHRNB2 (0.58) | KDM4EHSD17B10ALDH1A1HPGDTSHR | |
| SCHEMBL8444672 | 0.70 | KDM4E (0.68) | KDM4EHSD17B10ALDH1A1HPGDTSHR | |
| SCHEMBL5409935 | 0.70 | CHRNB2 (0.60) | KDM4EHSD17B10ALDH1A1HPGDTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1565455-A1 | INDOLYL PYRAZINONE DERIVATIVES USEFUL FOR TREATING HYPER-PROLIFERATIVE DISORDERS AND DISEASES ASSOCIATED WITH ANGIOGENESIS | Bayer Pharmaceuticals Corporation (US) | 2005-08-24 | — | — | EP | disclosed |
| WO-2004043950-A1 | INDOLYL PYRAZINONE DERIVATIVES USEFUL FOR TREATING HYPER-PROLIFERATIVE DISORDERS AND DISEASES ASSOCIATED WITH ANGIOGENESIS | BAYER PHARMACEUTICALS CORPORATION (US) | 2004-05-27 | — | — | WO | disclosed |