Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | PDE5A | O76074 | 4/20 | 0.51 |
| ▸ | APOBEC3A | P31941 | 3/20 | 0.49 |
| ▸ | APOBEC3G | Q9HC16 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | PDE6C | P51160 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6332580 | 0.90 | PDE5A (0.57) | KMT2APDE5AAPOBEC3AAPOBEC3GNPC1 | |
| SCHEMBL6200638 | 0.87 | PDE5A (0.68) | KMT2APDE5APKMALDH1A1KDM4E | |
| SCHEMBL6447294 | 0.86 | PDE5A (0.52) | KMT2APDE5ANPC1RAB9APKM | |
| SCHEMBL6200684 | 0.86 | PDE5A (0.60) | KMT2APDE5APDE6C | |
| SCHEMBL6444896 | 0.82 | PDE5A (0.62) | KMT2APDE5AALDH1A1KDM4EPDE6C | |
| SCHEMBL6444195 | 0.81 | PDE5A (0.56) | KMT2APDE5APKMALDH1A1KDM4E | |
| SCHEMBL6443153 | 0.81 | PDE5A (0.55) | KMT2APDE5AAPOBEC3AAPOBEC3GALDH1A1 | |
| SCHEMBL6446019 | 0.81 | PDE5A (0.55) | KMT2APDE5AAPOBEC3AAPOBEC3GALDH1A1 | |
| SCHEMBL6446584 | 0.80 | PDE5A (0.55) | KMT2APDE5AALDH1A1KDM4EPDE6C | |
| SCHEMBL7003161 | 0.80 | PDE5A (0.62) | KMT2APDE5ASMN1; SMN2NPC1PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0994115-B1 | Process for preparation of pyrazolo-(4,3-d)pyrimidin-7-ones and intermediates thereof | PFIZER LTD (GB) | 2005-03-02 | — | — | EP | disclosed |
| US-20030069422-A1 | Process for preparation of pyrazolo[4,3-d]pyrimidin-7-ones and intermediates thereof | DUNN PETER JAMES (GB) | 2003-04-10 | — | — | US | disclosed |
| US-6207829-B1 | CYCLIZATION OF A CORRESPONDING PYRAZOLE COMPOUND | PFIZER INC. | 2001-03-27 | — | — | US | disclosed |
| EP-0994115-A2 | Process for preparation of pyrazolo-(4,3-d)pyrimidin-7-ones and intermediates thereof | Pfizer Limited (GB) | 2000-04-19 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030069422-A1 | Process for preparation of pyrazolo[4,3-d]pyrimidin-7-ones and intermediates thereof | UGT2B7, CYP3A7, TOP2B | KMT2A 2876/4885PDE5A 1483/4885APOBEC3A 1239/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.