Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 1/20 | 0.52 |
| ▸ | CSNK2A1 | P68400 | 4/20 | 0.47 |
| ▸ | CSNK2A2 | P19784 | 3/20 | 0.47 |
| ▸ | CSNK2B | P67870 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | KDM3B | Q7LBC6 | 1/20 | 0.43 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.41 |
| ▸ | F7 | P08709 | 1/20 | 0.40 |
| ▸ | F3 | P13726 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.38 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.38 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.38 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.38 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.38 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.38 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.38 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6207236 | 0.77 | DYRK1A (0.47) | DYRK1ACSNK2A1CSNK2A2CSNK2BKDM4E | |
| SCHEMBL6207480 | 0.74 | KDM4E (0.44) | DYRK1ACSNK2A1CSNK2A2CSNK2BKDM4E | |
| SCHEMBL26708623 | 0.73 | DYRK1A (0.52) | DYRK1ACSNK2A1CSNK2A2CSNK2BKDM4E | |
| SCHEMBL547358 | 0.73 | NOTUM (0.50) | DYRK1ACSNK2A1CSNK2A2CSNK2BKDM4E | |
| SCHEMBL6023948 | 0.71 | NOTUM (0.46) | DYRK1ACSNK2A1CSNK2A2CSNK2BKDM4E | |
| SCHEMBL6208722 | 0.70 | KDM4E (0.44) | DYRK1ACSNK2A1CSNK2A2CSNK2BKDM4E | |
| SCHEMBL28944544 | 0.69 | NOTUM (0.50) | DYRK1ACSNK2A1CSNK2A2CSNK2BKDM4E | |
| SCHEMBL16654409 | 0.69 | DAO (0.33) | DYRK1ADAO | |
| SCHEMBL4784733 | 0.68 | KDM4E (0.39) | DYRK1ACSNK2A1CSNK2A2CSNK2BKDM4E | |
| SCHEMBL16918346 | 0.68 | DYRK1A (0.60) | DYRK1ACSNK2A1CSNK2A2CSNK2BKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1546133-A2 | N-SUBSTITUTE-2-OXODIHYDROPYRIDINE DERIVATIVES AS NPY ANTAGONISTS | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2005-06-29 | — | — | EP | disclosed |
| WO-2004031175-A2 | N-SUBSTITUTED-2-OXODIHYDROPYRIDINE DERIVATIVES AS NPY ANTAGONISTS | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2004-04-15 | — | — | WO | disclosed |