Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 8/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5530557 | 0.83 | ALDH1A1 (0.37) | KMT2AMAPTMEN1GAALMNA | |
| SCHEMBL15444916 | 0.76 | LMNA (0.38) | KMT2AMEN1GAALMNAKDM4E | |
| SCHEMBL17942309 | 0.61 | LMNA (0.57) | KMT2AMAPTMEN1GAALMNA | |
| SCHEMBL25979816 | 0.60 | CA1 (0.42) | KMT2AMAPTMEN1GAALMNA | |
| SCHEMBL16771373 | 0.60 | KMT2A (0.43) | KMT2AMAPTMEN1GAALMNA | |
| SCHEMBL17258007 | 0.60 | L3MBTL1 (0.40) | KMT2AMAPTMEN1LMNAKDM4E | |
| SCHEMBL17258006 | 0.60 | L3MBTL1 (0.40) | KMT2AMAPTMEN1LMNAKDM4E | |
| SCHEMBL9918736 | 0.59 | ALDH1A1 (0.50) | KMT2AMAPTMEN1GAALMNA | |
| SCHEMBL5173535 | 0.58 | STAT3 (0.39) | KMT2AMEN1GAALMNAALDH1A1 | |
| SCHEMBL15686531 | 0.58 | LMNA (0.53) | KMT2AMEN1GAALMNAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599469-A1 | TETRAZOLE DERIVATIVES AND METHODS OF TREATMENT OF METABOLIC-RELATED DISORDERS THEREOF | Arena Pharmaceuticals, Inc. (US) | 2005-11-30 | — | — | EP | disclosed |
| WO-2005044816-A1 | TETRAZOLE DERIVATIVES AND METHODS OF TREATMENT OF METABOLIC-RELATED DISORDERS THEREOF | ARENA PHARMACEUTICALS, INC. (US) | 2005-05-19 | — | — | WO | disclosed |