Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.56 |
| ▸ | CNR2 | P34972 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | LSS | P48449 | 1/20 | 0.50 |
| ▸ | SCN1A | P35498 | 2/20 | 0.49 |
| ▸ | SCN2A | Q99250 | 2/20 | 0.49 |
| ▸ | SCN3A | Q9NY46 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | PHLPP2 | Q6ZVD8 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11287086 | 0.87 | GAA (0.71) | GAAALDH1A1MAPK1HSD17B10TDP1 | |
| SCHEMBL14218219 | 0.84 | GAA (0.62) | GAAALDH1A1CNR2MAPK1TDP1 | |
| SCHEMBL8055450 | 0.83 | TDP1 (0.73) | GAAALDH1A1MAPK1HSD17B10TDP1 | |
| SCHEMBL9629064 | 0.82 | GAA (0.84) | GAAALDH1A1MAPK1HSD17B10TDP1 | |
| SCHEMBL11358749 | 0.82 | GAA (0.68) | GAAALDH1A1MAPK1HSD17B10TDP1 | |
| SCHEMBL27579412 | 0.81 | TDP1 (0.71) | GAAALDH1A1MAPK1HSD17B10TDP1 | |
| SCHEMBL11712702 | 0.80 | ALDH1A1 (0.48) | GAAALDH1A1CNR2MAPK1HSD17B10 | |
| SCHEMBL65544 | 0.77 | PHLPP2 (0.70) | GAAALDH1A1MAPK1TDP1SCN1A | |
| SCHEMBL14924442 | 0.76 | GAA (0.74) | GAAALDH1A1MAPK1TDP1SCN1A | |
| SCHEMBL26190076 | 0.76 | TDP1 (0.73) | ALDH1A1CNR2TDP1KDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1603921-A1 | THIADIBENZOAZULENE DERIVATIVES FOR THE TREATMENT OF INFLAMMATORY DISEASES | PLIVA-ISTRAZIVACKI INSTITUT d.o.o. (HR) | 2005-12-14 | — | — | EP | disclosed |
| WO-2004078763-A1 | THIADIBENZOAZULENE DERIVATIVES FOR THE TREATMENT OF INFLAMMATORY DISEASES | PLIVA-ISTRAZIVACKI INSTITUT D.O.O. (HR) | 2004-09-16 | — | — | WO | disclosed |