Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 4/20 | 0.61 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.61 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.61 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.50 |
| ▸ | DPP4 | P27487 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 4/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6208426 | 0.98 | SLC6A4 (0.64) | SLC6A4SLC6A3SLC6A2HSD11B1DPP4 | |
| SCHEMBL4866308 | 0.90 | DPP4 (0.58) | SLC6A4SLC6A3SLC6A2HSD11B1DPP4 | |
| SCHEMBL17761202 | 0.88 | DPP4 (0.56) | SLC6A4SLC6A3SLC6A2HSD11B1DPP4 | |
| SCHEMBL6499750 | 0.86 | HSD11B1 (0.65) | SLC6A4SLC6A3SLC6A2HSD11B1 | |
| SCHEMBL6494518 | 0.84 | HSD11B1 (0.68) | SLC6A4SLC6A3SLC6A2HSD11B1 | |
| SCHEMBL6500186 | 0.82 | SLC6A3 (0.57) | SLC6A4SLC6A3SLC6A2HSD11B1 | |
| SCHEMBL6494941 | 0.81 | SLC6A3 (0.60) | SLC6A4SLC6A3SLC6A2HSD11B1 | |
| SCHEMBL15873720 | 0.80 | HSD11B1 (0.49) | SLC6A4SLC6A3HSD11B1DPP4SMN1; SMN2 | |
| SCHEMBL12836588 | 0.80 | SLC6A4 (0.59) | SLC6A4SLC6A3SLC6A2HSD11B1ALDH1A1 | |
| SCHEMBL17761311 | 0.80 | HSD11B1 (0.71) | SLC6A4SLC6A3SLC6A2HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050234096-A1 | Tetrahydroisoquinoline derivatives | BAYER HEALTHCARE AG (DE) | 2005-10-20 | — | — | US | disclosed |
| EP-1507763-A1 | TETRAHYDROISOQUINOLINE DERIVATIVES | Bayer HealthCare AG (DE) | 2005-02-23 | — | — | EP | disclosed |
| WO-2003097607-A1 | TETRAHYDROISOQUINOLINE DERIVATIVES | BAYER HEALTHCARE AG (DE) | 2003-11-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050234096-A1 | Tetrahydroisoquinoline derivatives | PPARD, PPARG, PPARA | SLC6A4 3525/4885SLC6A3 3645/4885SLC6A2 3869/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.