Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A3 | Q01959 | 6/20 | 0.60 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.52 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.52 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.48 |
| ▸ | KIF11 | P52732 | 5/20 | 0.43 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.42 |
| ▸ | APP | P05067 | 1/20 | 0.40 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.39 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.39 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.39 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.39 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6500186 | 0.99 | SLC6A3 (0.57) | SLC6A3SLC6A4SLC6A2HSD11B1KIF11 | |
| SCHEMBL17761315 | 0.94 | SLC6A3 (0.62) | SLC6A3SLC6A4SLC6A2HSD11B1P2RX7 | |
| SCHEMBL17761293 | 0.91 | SLC6A3 (0.58) | SLC6A3SLC6A4SLC6A2HSD11B1P2RX7 | |
| SCHEMBL17761224 | 0.88 | SLC6A3 (0.53) | SLC6A3SLC6A4SLC6A2HSD11B1KIF11 | |
| SCHEMBL6494518 | 0.84 | HSD11B1 (0.68) | SLC6A3SLC6A4SLC6A2HSD11B1 | |
| SCHEMBL6499750 | 0.82 | HSD11B1 (0.65) | SLC6A3SLC6A4SLC6A2HSD11B1 | |
| SCHEMBL6208426 | 0.82 | SLC6A4 (0.64) | SLC6A3SLC6A4SLC6A2HSD11B1 | |
| SCHEMBL6208549 | 0.81 | SLC6A4 (0.61) | SLC6A3SLC6A4SLC6A2HSD11B1 | |
| SCHEMBL2835624 | 0.81 | SLC6A3 (0.90) | SLC6A3SLC6A4SLC6A2 | |
| SCHEMBL15867331 | 0.80 | SLC6A3 (0.62) | SLC6A3SLC6A4SLC6A2HSD11B1P2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050234096-A1 | Tetrahydroisoquinoline derivatives | BAYER HEALTHCARE AG (DE) | 2005-10-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050234096-A1 | Tetrahydroisoquinoline derivatives | PPARD, PPARG, PPARA | SLC6A3 3645/4885SLC6A4 3525/4885SLC6A2 3869/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.