Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 5/20 | 0.46 |
| ▸ | GSK3A | P49840 | 3/20 | 0.46 |
| ▸ | CDK1 | P06493 | 2/20 | 0.46 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.46 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.46 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.46 |
| ▸ | SIRT5 | Q9NXA8 | 3/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 5/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | CNR1 | P21554 | 2/20 | 0.33 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.32 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6210081 | 0.88 | GSK3B (0.51) | GSK3BGSK3ACDK1CCNB2CCNB1 | |
| SCHEMBL13423054 | 0.81 | GSK3B (0.46) | GSK3BGSK3ACDK1CCNB2CCNB1 | |
| SCHEMBL2903767 | 0.80 | GSK3B (0.45) | GSK3BGSK3ACDK1CCNB2CCNB1 | |
| SCHEMBL6429858 | 0.79 | GSK3B (0.52) | GSK3BGSK3ACDK1CCNB2CCNB1 | |
| SCHEMBL6213250 | 0.79 | GSK3B (0.51) | GSK3BGSK3ACDK1CCNB2CCNB1 | |
| SCHEMBL6408155 | 0.79 | SIRT5 (0.41) | GSK3BGSK3ACDK1CCNB2CCNB1 | |
| SCHEMBL6265338 | 0.77 | GSK3B (0.48) | GSK3BGSK3ACDK1CCNB2CCNB1 | |
| SCHEMBL2912125 | 0.71 | GSK3B (0.46) | GSK3BGSK3ACDK1CCNB2CCNB1 | |
| SCHEMBL2909753 | 0.71 | HPGD (0.47) | GSK3BGSK3ACDK1CCNB2CCNB1 | |
| SCHEMBL2937412 | 0.71 | GSK3B (0.46) | GSK3BGSK3ACDK1CCNB2CCNB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1537099-A1 | PYRROLE BASED INHIBITORS OF GLYCOGEN SYNTHASE KINASE 3 | CHIRON CORPORATION (US) | 2005-06-08 | — | — | EP | disclosed |
| WO-2004018455-A1 | PYRROLE BASED INHIBITORS OF GLYCOGEN SYNTHASE KINASE 3 | CHIRON CORPORATION (US) | 2004-03-04 | — | — | WO | disclosed |