Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT5 | Q9NXA8 | 2/20 | 0.41 |
| ▸ | GSK3B | P49841 | 6/20 | 0.39 |
| ▸ | GSK3A | P49840 | 4/20 | 0.39 |
| ▸ | CDK1 | P06493 | 2/20 | 0.39 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.39 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.39 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.39 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.36 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.36 |
| ▸ | FBP1 | P09467 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | EIF4E | P06730 | 1/20 | 0.34 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.34 |
| ▸ | AURKA | O14965 | 1/20 | 0.34 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
| ▸ | KDM1A | O60341 | 1/20 | 0.33 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6210081 | 0.86 | GSK3B (0.51) | SIRT5GSK3BGSK3ACDK1CCNB2 | |
| SCHEMBL6208619 | 0.79 | GSK3B (0.46) | SIRT5GSK3BGSK3ACDK1CCNB2 | |
| SCHEMBL6408156 | 0.79 | SIRT5 (0.39) | SIRT5GSK3BGSK3ACDK1CCNB2 | |
| SCHEMBL6213250 | 0.75 | GSK3B (0.51) | SIRT5GSK3BGSK3ACDK1CCNB2 | |
| SCHEMBL6429858 | 0.74 | GSK3B (0.52) | SIRT5GSK3BGSK3ACDK1CCNB2 | |
| SCHEMBL6265338 | 0.68 | GSK3B (0.48) | SIRT5GSK3BGSK3ACDK1CCNB2 | |
| SCHEMBL29695661 | 0.66 | GSK3B (0.61) | GSK3BGSK3APIN1MAPTL3MBTL1 | |
| SCHEMBL7189543 | 0.65 | GSK3B (0.56) | SIRT5GSK3BGSK3APIN1MAPT | |
| SCHEMBL7828769 | 0.65 | SIRT5 (0.64) | SIRT5STK17APIN1MAPTL3MBTL1 | |
| SCHEMBL6069007 | 0.65 | GSK3B (0.53) | GSK3BGSK3ACDK1CCNB2CCNB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1537099-A1 | PYRROLE BASED INHIBITORS OF GLYCOGEN SYNTHASE KINASE 3 | CHIRON CORPORATION (US) | 2005-06-08 | — | — | EP | disclosed |
| WO-2004018455-A1 | PYRROLE BASED INHIBITORS OF GLYCOGEN SYNTHASE KINASE 3 | CHIRON CORPORATION (US) | 2004-03-04 | — | — | WO | disclosed |