Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | KLK1 | P06870 | 2/20 | 0.37 |
| ▸ | KLK5 | Q9Y337 | 2/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.36 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.36 |
| ▸ | CTSS | P25774 | 1/20 | 0.35 |
| ▸ | CTSK | P43235 | 1/20 | 0.35 |
| ▸ | F10 | P00742 | 1/20 | 0.35 |
| ▸ | PARP1 | P09874 | 2/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | GRIN2D | O15399 | 2/20 | 0.34 |
| ▸ | GRIN3B | O60391 | 2/20 | 0.34 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.34 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.34 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.34 |
| ▸ | GRIN2C | Q14957 | 2/20 | 0.34 |
| ▸ | GRIN3A | Q8TCU5 | 2/20 | 0.34 |
| ▸ | TAS2R14 | Q9NYV8 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26135741 | 0.82 | LMNA (0.39) | LMNAGAAPTGS1KCNK3KCNK9 | |
| SCHEMBL29712527 | 0.82 | LMNA (0.50) | LMNAGAAPTGS1KCNK3KCNK9 | |
| SCHEMBL958496 | 0.82 | LMNA (0.50) | LMNAGAAPTGS1KCNK3KCNK9 | |
| SCHEMBL8513460 | 0.81 | PARP1 (0.47) | LMNAGAAPTGS1KCNK3KCNK9 | |
| Hydrochloric Acid SCHEMBL3065338 | 0.80 | LMNA (0.48) | LMNAGAAPTGS1F10GRIN2D | |
| Hydrochloric Acid SCHEMBL31138645 | 0.80 | LMNA (0.48) | LMNAGAAPTGS1F10GRIN2D | |
| Hydrochloric Acid SCHEMBL27788451 | 0.79 | LMNA (0.37) | LMNAGAAPTGS1CTSSCTSK | |
| Hydrochloric Acid SCHEMBL1259553 | 0.78 | LMNA (0.47) | LMNAGAAPTGS1GRIN2DGRIN3B | |
| SCHEMBL396017 | 0.76 | CA2 (0.55) | LMNAGAACA2ALDH1A1POLB | |
| SCHEMBL28052029 | 0.76 | LMNA (0.48) | LMNAGAAPTGS1KCNK3KCNK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014062938-A1 | RORY MODULATORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2014-04-24 | — | — | WO | disclosed |
| CN-101115482-A | Heterocyclic aspartyl protease inhibitors | SCHERING CORP (US) | 2008-01-30 | — | — | CN | disclosed |
| EP-1458392-A4 | ACRIDONE INHIBITORS OF IMPDH ENZYME | BRISTOL MYERS SQUIBB CO (US) | 2005-06-08 | — | — | EP | disclosed |
| EP-1458392-A2 | ACRIDONE INHIBITORS OF IMPDH ENZYME | Bristol-Myers Squibb Company (US) | 2004-09-22 | — | — | EP | disclosed |
| WO-2003059269-A2 | ACRIDONE INHIBITORS OF IMPDH ENZYME | BRISTOL-MYERS SQUIBB COMPANY (US) | 2003-07-24 | — | — | WO | disclosed |